The Met tyrosine kinase receptor in development and cancer

Alessandra Gentile, Livio Trusolino, Paolo M. Comoglio

Research output: Contribution to journalArticle

Abstract

Met is a tyrosine kinase receptor, encoded by an oncogene, whose crucial role has been elucidated during the last two decades. The complex biological program triggered by Met has been dissected and its biological relevance in both physiology and pathology has been proven. Met supports a morphogenetic program, known as invasive growth, taking place both during embryogenesis and adulthood. In tumors Met is often aberrantly activated, giving rise to the pathological counterpart of the invasive growth program: cancer progression towards metastasis. Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalCANCER AND METASTASIS REVIEW
Volume27
Issue number1
DOIs
Publication statusPublished - Mar 2008

Keywords

  • "Invasive growth"
  • HGF
  • Met
  • Metastasis
  • Tyrosine kinase receptor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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