The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

Elisabetta Caletti; Giorgio Marotta; Giuseppe Del Vecchio; Riccardo A. Paoli; Michela Cigliobianco; Cecilia Prunas; Elisa Zugno; Francesca Bottinelli; Paolo Brambilla; A. Carlo Altamura

doi:10.1371/journal.pone.0175803

The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

Elisabetta Caletti, Giorgio Marotta, Giuseppe Del Vecchio, Riccardo A. Paoli, Michela Cigliobianco, Cecilia Prunas, Elisa Zugno, Francesca Bottinelli, Paolo Brambilla, A. Carlo Altamura

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.

Original language	English
Article number	e0175803
Journal	PLoS One
Volume	12
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0175803
Publication status	Published - Apr 1 2017

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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The metabolic basis of cognitive insight in psychosis : A positron emission tomography study. / Caletti, Elisabetta ; Marotta, Giorgio; Del Vecchio, Giuseppe; Paoli, Riccardo A.; Cigliobianco, Michela; Prunas, Cecilia; Zugno, Elisa; Bottinelli, Francesca; Brambilla, Paolo; Altamura, A. Carlo.

In: PLoS One, Vol. 12, No. 4, e0175803, 01.04.2017.

Research output: Contribution to journal › Article › peer-review

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AU - Prunas, Cecilia

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