TY - JOUR
T1 - The metabolic basis of cognitive insight in psychosis
T2 - A positron emission tomography study
AU - Caletti, Elisabetta
AU - Marotta, Giorgio
AU - Del Vecchio, Giuseppe
AU - Paoli, Riccardo A.
AU - Cigliobianco, Michela
AU - Prunas, Cecilia
AU - Zugno, Elisa
AU - Bottinelli, Francesca
AU - Brambilla, Paolo
AU - Altamura, A. Carlo
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.
AB - The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.
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U2 - 10.1371/journal.pone.0175803
DO - 10.1371/journal.pone.0175803
M3 - Article
C2 - 28414766
AN - SCOPUS:85017575590
VL - 12
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 4
M1 - e0175803
ER -