The metabolic basis of cognitive insight in psychosis: A positron emission tomography study

E. Caletti, G. Marotta, Giuseppe Del Vecchio, R.A. Paoli, M. Cigliobianco, C. Prunas, E. Zugno, F. Bottinelli, P. Brambilla, A.C. Altamura

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Abstract

The purpose of this study was to investigate the relationship between cognitive insight and cerebral metabolism in patients suffering from psychosis. The Beck Cognitive Insight Scale (BCIS) was administered to 63 patients with psychosis undergoing Positron Emission Tomography investigation. The sample was divided into two groups considering the BCIS score. Data were analyzed using Statistical Parametric Mapping. Results: patients with low insight, compared to those with high insight, showed decreased metabolism in the right fusiform gyrus, left precuneus, superior temporal gyrus and insula bilaterally, as well as increased metabolism in the left orbito-frontal gyrus (all p<0.005). Our results suggest that reduced posterior (occipito-temporo-insulo-parietal) and increased anterior (orbitofrontal) cerebral metabolism may sustain low cognitive insight in psychosis.
Original languageEnglish
Article numbere0175803
JournalPLoS One
Volume12
Issue number4
DOIs
Publication statusPublished - 2017

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positron-emission tomography
Positron emission tomography
Metabolism
Positron-Emission Tomography
Psychotic Disorders
metabolism
Temporal Lobe
Parietal Lobe
sampling

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The metabolic basis of cognitive insight in psychosis: A positron emission tomography study. / Caletti, E.; Marotta, G.; Del Vecchio, Giuseppe; Paoli, R.A.; Cigliobianco, M.; Prunas, C.; Zugno, E.; Bottinelli, F.; Brambilla, P.; Altamura, A.C.

In: PLoS One, Vol. 12, No. 4, e0175803, 2017.

Research output: Contribution to journalArticle

Caletti, E. ; Marotta, G. ; Del Vecchio, Giuseppe ; Paoli, R.A. ; Cigliobianco, M. ; Prunas, C. ; Zugno, E. ; Bottinelli, F. ; Brambilla, P. ; Altamura, A.C. / The metabolic basis of cognitive insight in psychosis: A positron emission tomography study. In: PLoS One. 2017 ; Vol. 12, No. 4.
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AU - Del Vecchio, Giuseppe

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AU - Cigliobianco, M.

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AU - Zugno, E.

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AU - Brambilla, P.

AU - Altamura, A.C.

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