The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino

Research output: Contribution to journalReview articlepeer-review

Abstract

Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.

Original languageEnglish
JournalCells
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 15 2021

Keywords

  • diabetes
  • GRK2
  • heart failure
  • hypertension
  • insulin resistance

ASJC Scopus subject areas

  • Medicine(all)

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