The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

Daniela Sorriento; Maria Rosaria Rusciano; Valeria Visco; Antonella Fiordelisi; Federica Andrea Cerasuolo; Paolo Poggio; Michele Ciccarelli; Guido Iaccarino

doi:10.3390/cells10010167

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions

Daniela Sorriento, Maria Rosaria Rusciano, Valeria Visco, Antonella Fiordelisi, Federica Andrea Cerasuolo, Paolo Poggio, Michele Ciccarelli, Guido Iaccarino

Research output: Contribution to journal › Review article › peer-review

Abstract

Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.

Original language	English
Journal	Cells
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/cells10010167
Publication status	Published - Jan 15 2021

Keywords

diabetes
GRK2
heart failure
hypertension
insulin resistance

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.3390/cells10010167

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title = "The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions",

abstract = "Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.",

keywords = "diabetes, GRK2, heart failure, hypertension, insulin resistance",

author = "Daniela Sorriento and Rusciano, {Maria Rosaria} and Valeria Visco and Antonella Fiordelisi and Cerasuolo, {Federica Andrea} and Paolo Poggio and Michele Ciccarelli and Guido Iaccarino",

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AU - Sorriento, Daniela

AU - Rusciano, Maria Rosaria

AU - Visco, Valeria

AU - Fiordelisi, Antonella

AU - Cerasuolo, Federica Andrea

AU - Poggio, Paolo

AU - Ciccarelli, Michele

AU - Iaccarino, Guido

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.

AB - Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.

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