TY - JOUR
T1 - The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions
AU - Sorriento, Daniela
AU - Rusciano, Maria Rosaria
AU - Visco, Valeria
AU - Fiordelisi, Antonella
AU - Cerasuolo, Federica Andrea
AU - Poggio, Paolo
AU - Ciccarelli, Michele
AU - Iaccarino, Guido
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2021/1/15
Y1 - 2021/1/15
N2 - Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.
AB - Insulin resistance (IRES) is a pathophysiological condition characterized by the reduced response to insulin of several tissues, including myocardial and skeletal muscle. IRES is associated with obesity, glucose intolerance, dyslipidemia, and hypertension, evolves toward type 2 diabetes, and increases the risk of developing cardiovascular diseases. Several studies designed to explore the mechanisms involved in IRES allowed the identification of a multitude of potential molecular targets. Among the most promising, G Protein Coupled Receptor Kinase type 2 (GRK2) appears to be a suitable one given its functional implications in many cellular processes. In this review, we will discuss the metabolic role of GRK2 in those conditions that are characterized by insulin resistance (diabetes, hypertension, heart failure), and the potentiality of its inhibition as a therapeutic strategy to revert both insulin resistance and its associated phenotypes.
KW - diabetes
KW - GRK2
KW - heart failure
KW - hypertension
KW - insulin resistance
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U2 - 10.3390/cells10010167
DO - 10.3390/cells10010167
M3 - Review article
C2 - 33467677
AN - SCOPUS:85100226670
VL - 10
JO - Cells
JF - Cells
SN - 2073-4409
IS - 1
ER -