The metabolic syndrome predicts carotid intima-media thickness no better than the sum of individual risk factors in a lipid clinic population

Research output: Contribution to journalArticle

Abstract

Objective: To assess whether the diagnosis 'metabolic syndrome' (MS) predicts the degree of subclinical atherosclerosis better than its component parts or the total number of vascular risk factors (VRFs) in patients attending a lipid clinic. Methods: Carotid intima-media thickness (C-IMT) was measured by B-mode ultrasound in 1804 patients (56 ± 13 years; 52% women). To investigate whether the increased subclinical carotid atherosclerosis often ascribed to MS may be explained by a real interaction between the components or simply by a sum of VRFs, observed C-IMTs were compared with those predicted by the sum of individual components. Values for C-IMT of MS patients were also compared with those of controls matched for number of VRFs or for SCORE predicted risk (SPR). Results: Carotid IMT values were significantly higher in patients with MS (n=362) than in those not so diagnosed (IMTmean, 1.07±0.37 vs. 0.95±0.33; IMTmax, 1.98±0.93mm vs. 1.67±0.82mm, both p

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalAtherosclerosis
Volume210
Issue number1
DOIs
Publication statusPublished - May 2010

Keywords

  • Dyslipidemia
  • Intima-media thickness
  • Metabolic syndrome
  • Vascular risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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