TY - JOUR
T1 - The methyl donor S-adenosylmethionine potentiates doxorubicin effects on apoptosis of hormone-dependent breast cancer cell lines
AU - Ilisso, Concetta Paola
AU - Castellano, Maria
AU - Zappavigna, Silvia
AU - Lombardi, Angela
AU - Vitale, Giovanni
AU - Dicitore, Alessandra
AU - Cacciapuoti, Giovanna
AU - Caraglia, Michele
AU - Porcelli, Marina
PY - 2015/9/25
Y1 - 2015/9/25
N2 - In this work, we have investigated the antiproliferative effect of AdoMet and Doxorubicin (Doxo), alone or in combination, on different breast cancer cell lines. For the evaluation of synergism, we have calculated the combination index (CI) by the Calcusyn software and we have evaluated the effects of the combination on apoptosis occurrence at FACS analysis in hormone-dependent CG5 cell line. We have found that AdoMet and Doxo given in combination were strongly synergistic in the hormone-dependent CG5 and MCF-7 human breast cancer cell line, as a CI50
AB - In this work, we have investigated the antiproliferative effect of AdoMet and Doxorubicin (Doxo), alone or in combination, on different breast cancer cell lines. For the evaluation of synergism, we have calculated the combination index (CI) by the Calcusyn software and we have evaluated the effects of the combination on apoptosis occurrence at FACS analysis in hormone-dependent CG5 cell line. We have found that AdoMet and Doxo given in combination were strongly synergistic in the hormone-dependent CG5 and MCF-7 human breast cancer cell line, as a CI50
KW - Cytotoxicity
KW - Doxorubicin
KW - Drug combination
KW - Hormone-dependent breast cancer cell line CG5
KW - S-adenosylmethionine
UR - http://www.scopus.com/inward/record.url?scp=84938911472&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84938911472&partnerID=8YFLogxK
U2 - 10.1007/s12020-014-0484-7
DO - 10.1007/s12020-014-0484-7
M3 - Article
C2 - 25577236
AN - SCOPUS:84938911472
VL - 50
SP - 212
EP - 222
JO - Endocrine
JF - Endocrine
SN - 1355-008X
IS - 1
ER -