The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

Maria Giulia Bacalini, Patrizia D'Aquila, Elena Marasco, Christine Nardini, Alberto Montesanto, Claudio Franceschi, Giuseppe Passarino, Paolo Garagnani, Dina Bellizzi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a progressive process of genome demethylation, in a hypermethylation of gene-specific CpG dinucleotides, as well as in an inter-individual divergence of the epigenome due to stochastic events and environmental exposures throughout life, namely as epigenetic drift.Additionally, it has also come to light an implication of the mitochondrial genome in the regulation of the intracellular epigenetic landscape, as demonstrated by the being itself object of epigenetic modifications.An overview of DNA methylation changes occurring during ageing process at both nuclear and mitochondrial level will be described in this review, also taking into account the recent and promising data available on the 5-hydroxymethylcytosine.

Original languageEnglish
Pages (from-to)156-61
JournalMechanisms of Ageing and Development
Volume165
Issue numberPt B
DOIs
Publication statusPublished - 2017

Fingerprint

Mitochondrial DNA
Epigenomics
Methylation
Phenotype
DNA Methylation
Mitochondrial Genome
Environmental Exposure
Genome
Genes

Keywords

  • Ageing
  • Ageing phenotypes
  • Centenarians
  • Epigenetic clock
  • Epigenetic drift
  • Longevity
  • Mitochondrial DNA methylation
  • Nuclear DNA methylation

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

Cite this

Bacalini, M. G., D'Aquila, P., Marasco, E., Nardini, C., Montesanto, A., Franceschi, C., ... Bellizzi, D. (2017). The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity. Mechanisms of Ageing and Development, 165(Pt B), 156-61. https://doi.org/10.1016/j.mad.2017.01.006

The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity. / Bacalini, Maria Giulia; D'Aquila, Patrizia; Marasco, Elena; Nardini, Christine; Montesanto, Alberto; Franceschi, Claudio; Passarino, Giuseppe; Garagnani, Paolo; Bellizzi, Dina.

In: Mechanisms of Ageing and Development, Vol. 165, No. Pt B, 2017, p. 156-61.

Research output: Contribution to journalArticle

Bacalini, MG, D'Aquila, P, Marasco, E, Nardini, C, Montesanto, A, Franceschi, C, Passarino, G, Garagnani, P & Bellizzi, D 2017, 'The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity', Mechanisms of Ageing and Development, vol. 165, no. Pt B, pp. 156-61. https://doi.org/10.1016/j.mad.2017.01.006
Bacalini, Maria Giulia ; D'Aquila, Patrizia ; Marasco, Elena ; Nardini, Christine ; Montesanto, Alberto ; Franceschi, Claudio ; Passarino, Giuseppe ; Garagnani, Paolo ; Bellizzi, Dina. / The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity. In: Mechanisms of Ageing and Development. 2017 ; Vol. 165, No. Pt B. pp. 156-61.
@article{6f5298fb0370431ab338e1059bd944d4,
title = "The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity",
abstract = "An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a progressive process of genome demethylation, in a hypermethylation of gene-specific CpG dinucleotides, as well as in an inter-individual divergence of the epigenome due to stochastic events and environmental exposures throughout life, namely as epigenetic drift.Additionally, it has also come to light an implication of the mitochondrial genome in the regulation of the intracellular epigenetic landscape, as demonstrated by the being itself object of epigenetic modifications.An overview of DNA methylation changes occurring during ageing process at both nuclear and mitochondrial level will be described in this review, also taking into account the recent and promising data available on the 5-hydroxymethylcytosine.",
keywords = "Ageing, Ageing phenotypes, Centenarians, Epigenetic clock, Epigenetic drift, Longevity, Mitochondrial DNA methylation, Nuclear DNA methylation",
author = "Bacalini, {Maria Giulia} and Patrizia D'Aquila and Elena Marasco and Christine Nardini and Alberto Montesanto and Claudio Franceschi and Giuseppe Passarino and Paolo Garagnani and Dina Bellizzi",
note = "Il Prof. Claudio Franceschi viene da altro Istituto e lavori con affiliazioni diverse usciranno ancora nei prossimi anni",
year = "2017",
doi = "10.1016/j.mad.2017.01.006",
language = "English",
volume = "165",
pages = "156--61",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "Pt B",

}

TY - JOUR

T1 - The methylation of nuclear and mitochondrial DNA in ageing phenotypes and longevity

AU - Bacalini, Maria Giulia

AU - D'Aquila, Patrizia

AU - Marasco, Elena

AU - Nardini, Christine

AU - Montesanto, Alberto

AU - Franceschi, Claudio

AU - Passarino, Giuseppe

AU - Garagnani, Paolo

AU - Bellizzi, Dina

N1 - Il Prof. Claudio Franceschi viene da altro Istituto e lavori con affiliazioni diverse usciranno ancora nei prossimi anni

PY - 2017

Y1 - 2017

N2 - An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a progressive process of genome demethylation, in a hypermethylation of gene-specific CpG dinucleotides, as well as in an inter-individual divergence of the epigenome due to stochastic events and environmental exposures throughout life, namely as epigenetic drift.Additionally, it has also come to light an implication of the mitochondrial genome in the regulation of the intracellular epigenetic landscape, as demonstrated by the being itself object of epigenetic modifications.An overview of DNA methylation changes occurring during ageing process at both nuclear and mitochondrial level will be described in this review, also taking into account the recent and promising data available on the 5-hydroxymethylcytosine.

AB - An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ageing, consisting mainly in a progressive process of genome demethylation, in a hypermethylation of gene-specific CpG dinucleotides, as well as in an inter-individual divergence of the epigenome due to stochastic events and environmental exposures throughout life, namely as epigenetic drift.Additionally, it has also come to light an implication of the mitochondrial genome in the regulation of the intracellular epigenetic landscape, as demonstrated by the being itself object of epigenetic modifications.An overview of DNA methylation changes occurring during ageing process at both nuclear and mitochondrial level will be described in this review, also taking into account the recent and promising data available on the 5-hydroxymethylcytosine.

KW - Ageing

KW - Ageing phenotypes

KW - Centenarians

KW - Epigenetic clock

KW - Epigenetic drift

KW - Longevity

KW - Mitochondrial DNA methylation

KW - Nuclear DNA methylation

UR - http://www.scopus.com/inward/record.url?scp=85012884097&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012884097&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2017.01.006

DO - 10.1016/j.mad.2017.01.006

M3 - Article

C2 - 28115210

AN - SCOPUS:85012884097

VL - 165

SP - 156

EP - 161

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - Pt B

ER -