The Microbiome of the Prostate Tumor Microenvironment

I Cavarretta, R Ferrarese, W Cazzaniga, D Saita, R Lucianò, ER Ceresola, Irene Locatelli, Laura Visconti, G Lavorgna, A Briganti, M Nebuloni, C Doglioni, M Clementi, F Montorsi, F Canducci, A Salonia

Research output: Contribution to journalArticlepeer-review


Background: The advent of molecular-based methods of identification and characterization of complex microbial populations has led to a new era of microbial discovery. A detailed and comprehensive analysis of the microbial ecosystem of the pathologic and healthy prostate tissues has not been yet reported. Objectives: To characterize the microbiome possibly associated to the pathologic prostate microenvironment. Design, setting, and participants: The microbiome profile of tumor, peri-tumor, and nontumor tissues was assessed on 16 radical prostatectomy-specimens. Outcome measurements and statistical analysis: Microbiome analysis was assessed by massive ultradeep pyrosequencing. Bacteria load was expressed as a percentage of the total number of bacteria. The statistical significance of differences among specimen-groups was tested with Friedman's test (Dunn posthoc test) and Wilcoxon rank-sum test. Results and limitations: Three phyla, six classes, nine orders, 14 families, and 11 genera were above the set threshold value of 1%, respectively. Significant differences in specific microbial populations among tumor/peri-tumor and nontumor prostate specimens were observed at certain taxonomic levels. Among genera, Propionibacterium spp. were the most abundant. Staphylococcus spp. were more represented in the tumor/peri-tumor tissues (p
Original languageEnglish
Pages (from-to)625-631
Number of pages7
JournalEuropean Urology
Issue number4
Publication statusPublished - 2017


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