The microbiota revolution: Excitement and caution

Research output: Contribution to journalReview articlepeer-review


Scientific progress is characterized by important technological advances. Next-generation DNA sequencing has, in the past few years, led to a major scientific revolution: the microbiome revolution. It has become possible to generate a fingerprint of the whole microbiota of any given environment. As it becomes clear that the microbiota affects several aspects of our lives, each new scientific finding should ideally be analyzed in light of these communities. For instance, animal experimentation should consider animal sources and husbandry; human experimentation should include analysis of microenvironmental cues that might affect the microbiota, including diet, antibiotic, and drug use, genetics. When analyzing the activity of a drug, we should remember that, according to the microbiota of the host, different drug activities might be observed, either due to modification or degradation by the microbiota, or because the microbiota changes the immune system of the host in a way that makes that drug more or less effective. This minireview will not be a comprehensive review on the interaction between the host and microbiota, but it will aim at creating awareness on why we should not forget the contribution of the microbiota in any single aspect of biology.

Original languageEnglish
Pages (from-to)1406-1413
Number of pages8
JournalEuropean Journal of Immunology
Issue number9
Publication statusPublished - Sep 1 2017


  • Host–microbe
  • Intestinal epithelium
  • Microbiota
  • Models
  • Research methods
  • Tissues

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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