In lymphomas, it is increasingly apparent that the microenvironment is an essential player not only for lymphoma pathogenesis but also for diseaseprogression and therapy resistance. In recent years, we have begun to understand the complex crosstalk between the neoplastic cells and other immunecells, such as T and NK cells, and stromal cells, as well as the signaling pathways that become aberrantly activated through this dialogue (e.g. B-cellreceptor, Toll-like receptor and NF-kB signaling). In this series of reviews, the intricate interplay between lymphoma cells and 'by-stander' cells will beillustrated in representative lymphoma entities, namely Hodgkin lymphomas, follicular lymphomas, marginal-zone lymphomas, chronic lymphocyticleukemia, and T-cell lymphomas, where the crucial role played by the microenvironment has become particularly evident. Furthermore, important cluesto the pathobiology of lymphomas have emerged from (i) the recognition of pre-malignant conditions, such as monoclonal B-cell lymphocytosis or in situlymphomas, (ii) the identification of microbial and/or auto-antigens that are linked to particular entities, as well as (iii) the established increased riskof lymphomas in certain autoimmune/inflammatory conditions, all critical aspects that will be further elaborated in this thematic issue. Our increasingknowledge of these interactions and associations has finally allowed us to design targeted or immune-mediated strategies to interfere with the lymphomamicroenvironment, thereby opening promising therapeutic avenues on the road to cure for these yet incurable diseases.
ASJC Scopus subject areas
- Cancer Research