The mitochondrial permeability transition pore and cyclophilin D in cardioprotection

Fabio Di Lisa, Andrea Carpi, Valentina Giorgio, Paolo Bernardi

Research output: Contribution to journalArticle

Abstract

Mitochondria play a central role in heart energy metabolism and Ca2+ homeostasis and are involved in the pathogenesis of many forms of heart disease. The body of knowledge on mitochondrial pathophysiology in living cells and organs is increasing, and so is the interest in mitochondria as potential targets for cardioprotection. This critical review will focus on the permeability transition pore (PTP) and its regulation by cyclophilin (CyP) D as effectors of endogenous protective mechanisms and as potential drug targets. The complexity of the regulatory interactions underlying control of mitochondrial function in vivo is beginning to emerge, and although apparently contradictory findings still exist we believe that the network of regulatory protein interactions involving the PTP and CyPs in physiology and pathology will increase our repertoire for therapeutic interventions in heart disease. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

Original languageEnglish
Pages (from-to)1316-1322
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number7
DOIs
Publication statusPublished - Jul 2011

Keywords

  • Cardioprotection
  • Cyclophilin D
  • Heart
  • Mitochondria
  • Permeability transition

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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