The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B-cell and diffuse large B-cell histologies

Sergio Cortelazzo, Andrea Rossi, Elena Oldani, Teresio Motta, Roberto Giardini, Pier Luigi Zinzani, Emanuele Zucca, Henry Gomez, Andrés J M Ferreri, Graziella Pinotti, Claudio Chini, Liliana Devizzi, Alessandro M. Gianni, Franco Cavalli, Tiziano Barbui

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18 Citations (Scopus)

Abstract

We have previously reported on the efficacy of a modified International Prognostic Index (MIPI) in predicting the outcome of patients with primary gastric lymphoma. This prompted the retrospective analysis of a large series of patients with primary intestinal lymphoma (PIL) of both diffuse large B-cell (DLCL) and low-grade (extranodal marginal zone B-cell lymphoma, MZL) histology. Clinical records of 122 patients with localized primary intestinal lymphoma of MZL (n = 35) and DLCL (n = 87) histology, confirmed by an ad hoc expert panel of pathologists, were reviewed. Forty-nine patients were treated with single therapy, while 72 received combined-modality treatment, which included surgery followed by a short-term chemotherapy. MIPI was included in a multivariate prognostic analysis for overall survival (OS) and event-free survival (EFS). Sixty-five patients (75%) with DLCL and 22 with MZL (65%) achieved complete remission. After a median follow-up of 42 months (range 6-163 months), 5-year estimates of OS and EFS were 68% and 50% for DLCL and 65% and 26% for MZL. OS varied according to MIPI, from, respectively, 86% and 87% for DLCL and MZL patients with 0-1 risk factor to 50% and 32% for patients with > 1 risk factor (P = 0.01 and P = 0.02). Similar results were obtained for EFS. Cox regression analysis showed an unfavourable MIPI to be the only independent predictor of shorter EFS. This retrospective study shows that stage-MIPI can be a reliable prognostic indicator for PIL of both low-grade MZL and diffuse large B-cell histology, enabling the early identification of patients at higher risk of failure.

Original languageEnglish
Pages (from-to)218-228
Number of pages11
JournalBritish Journal of Haematology
Volume118
Issue number1
DOIs
Publication statusPublished - 2002

Fingerprint

Lymphoma
Histology
B-Lymphocytes
Disease-Free Survival
Survival
Marginal Zone B-Cell Lymphoma
Lymphoma, Large B-Cell, Diffuse
Non-Hodgkin's Lymphoma
Multivariate Analysis
Retrospective Studies
Regression Analysis
Drug Therapy
Therapeutics

Keywords

  • Diffuse large B-cell lymphoma (DLCL)
  • Extranodal marginal zone B-cell lymphoma (MZL)
  • Modified international prognostic index (MIPI)
  • Primary intestinal lymphoma (PIL)

ASJC Scopus subject areas

  • Hematology

Cite this

The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B-cell and diffuse large B-cell histologies. / Cortelazzo, Sergio; Rossi, Andrea; Oldani, Elena; Motta, Teresio; Giardini, Roberto; Zinzani, Pier Luigi; Zucca, Emanuele; Gomez, Henry; Ferreri, Andrés J M; Pinotti, Graziella; Chini, Claudio; Devizzi, Liliana; Gianni, Alessandro M.; Cavalli, Franco; Barbui, Tiziano.

In: British Journal of Haematology, Vol. 118, No. 1, 2002, p. 218-228.

Research output: Contribution to journalArticle

Cortelazzo, Sergio ; Rossi, Andrea ; Oldani, Elena ; Motta, Teresio ; Giardini, Roberto ; Zinzani, Pier Luigi ; Zucca, Emanuele ; Gomez, Henry ; Ferreri, Andrés J M ; Pinotti, Graziella ; Chini, Claudio ; Devizzi, Liliana ; Gianni, Alessandro M. ; Cavalli, Franco ; Barbui, Tiziano. / The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B-cell and diffuse large B-cell histologies. In: British Journal of Haematology. 2002 ; Vol. 118, No. 1. pp. 218-228.
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AU - Rossi, Andrea

AU - Oldani, Elena

AU - Motta, Teresio

AU - Giardini, Roberto

AU - Zinzani, Pier Luigi

AU - Zucca, Emanuele

AU - Gomez, Henry

AU - Ferreri, Andrés J M

AU - Pinotti, Graziella

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