Abstract
We have previously reported on the efficacy of a modified International Prognostic Index (MIPI) in predicting the outcome of patients with primary gastric lymphoma. This prompted the retrospective analysis of a large series of patients with primary intestinal lymphoma (PIL) of both diffuse large B-cell (DLCL) and low-grade (extranodal marginal zone B-cell lymphoma, MZL) histology. Clinical records of 122 patients with localized primary intestinal lymphoma of MZL (n = 35) and DLCL (n = 87) histology, confirmed by an ad hoc expert panel of pathologists, were reviewed. Forty-nine patients were treated with single therapy, while 72 received combined-modality treatment, which included surgery followed by a short-term chemotherapy. MIPI was included in a multivariate prognostic analysis for overall survival (OS) and event-free survival (EFS). Sixty-five patients (75%) with DLCL and 22 with MZL (65%) achieved complete remission. After a median follow-up of 42 months (range 6-163 months), 5-year estimates of OS and EFS were 68% and 50% for DLCL and 65% and 26% for MZL. OS varied according to MIPI, from, respectively, 86% and 87% for DLCL and MZL patients with 0-1 risk factor to 50% and 32% for patients with > 1 risk factor (P = 0.01 and P = 0.02). Similar results were obtained for EFS. Cox regression analysis showed an unfavourable MIPI to be the only independent predictor of shorter EFS. This retrospective study shows that stage-MIPI can be a reliable prognostic indicator for PIL of both low-grade MZL and diffuse large B-cell histology, enabling the early identification of patients at higher risk of failure.
| Original language | English |
|---|---|
| Pages (from-to) | 218-228 |
| Number of pages | 11 |
| Journal | British Journal of Haematology |
| Volume | 118 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- Diffuse large B-cell lymphoma (DLCL)
- Extranodal marginal zone B-cell lymphoma (MZL)
- Modified international prognostic index (MIPI)
- Primary intestinal lymphoma (PIL)
ASJC Scopus subject areas
- Hematology
Cite this
The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B-cell and diffuse large B-cell histologies. / Cortelazzo, Sergio; Rossi, Andrea; Oldani, Elena; Motta, Teresio; Giardini, Roberto; Zinzani, Pier Luigi; Zucca, Emanuele; Gomez, Henry; Ferreri, Andrés J M; Pinotti, Graziella; Chini, Claudio; Devizzi, Liliana; Gianni, Alessandro M.; Cavalli, Franco; Barbui, Tiziano.
In: British Journal of Haematology, Vol. 118, No. 1, 2002, p. 218-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The modified International Prognostic Index can predict the outcome of localized primary intestinal lymphoma of both extranodal marginal zone B-cell and diffuse large B-cell histologies
AU - Cortelazzo, Sergio
AU - Rossi, Andrea
AU - Oldani, Elena
AU - Motta, Teresio
AU - Giardini, Roberto
AU - Zinzani, Pier Luigi
AU - Zucca, Emanuele
AU - Gomez, Henry
AU - Ferreri, Andrés J M
AU - Pinotti, Graziella
AU - Chini, Claudio
AU - Devizzi, Liliana
AU - Gianni, Alessandro M.
AU - Cavalli, Franco
AU - Barbui, Tiziano
PY - 2002
Y1 - 2002
N2 - We have previously reported on the efficacy of a modified International Prognostic Index (MIPI) in predicting the outcome of patients with primary gastric lymphoma. This prompted the retrospective analysis of a large series of patients with primary intestinal lymphoma (PIL) of both diffuse large B-cell (DLCL) and low-grade (extranodal marginal zone B-cell lymphoma, MZL) histology. Clinical records of 122 patients with localized primary intestinal lymphoma of MZL (n = 35) and DLCL (n = 87) histology, confirmed by an ad hoc expert panel of pathologists, were reviewed. Forty-nine patients were treated with single therapy, while 72 received combined-modality treatment, which included surgery followed by a short-term chemotherapy. MIPI was included in a multivariate prognostic analysis for overall survival (OS) and event-free survival (EFS). Sixty-five patients (75%) with DLCL and 22 with MZL (65%) achieved complete remission. After a median follow-up of 42 months (range 6-163 months), 5-year estimates of OS and EFS were 68% and 50% for DLCL and 65% and 26% for MZL. OS varied according to MIPI, from, respectively, 86% and 87% for DLCL and MZL patients with 0-1 risk factor to 50% and 32% for patients with > 1 risk factor (P = 0.01 and P = 0.02). Similar results were obtained for EFS. Cox regression analysis showed an unfavourable MIPI to be the only independent predictor of shorter EFS. This retrospective study shows that stage-MIPI can be a reliable prognostic indicator for PIL of both low-grade MZL and diffuse large B-cell histology, enabling the early identification of patients at higher risk of failure.
AB - We have previously reported on the efficacy of a modified International Prognostic Index (MIPI) in predicting the outcome of patients with primary gastric lymphoma. This prompted the retrospective analysis of a large series of patients with primary intestinal lymphoma (PIL) of both diffuse large B-cell (DLCL) and low-grade (extranodal marginal zone B-cell lymphoma, MZL) histology. Clinical records of 122 patients with localized primary intestinal lymphoma of MZL (n = 35) and DLCL (n = 87) histology, confirmed by an ad hoc expert panel of pathologists, were reviewed. Forty-nine patients were treated with single therapy, while 72 received combined-modality treatment, which included surgery followed by a short-term chemotherapy. MIPI was included in a multivariate prognostic analysis for overall survival (OS) and event-free survival (EFS). Sixty-five patients (75%) with DLCL and 22 with MZL (65%) achieved complete remission. After a median follow-up of 42 months (range 6-163 months), 5-year estimates of OS and EFS were 68% and 50% for DLCL and 65% and 26% for MZL. OS varied according to MIPI, from, respectively, 86% and 87% for DLCL and MZL patients with 0-1 risk factor to 50% and 32% for patients with > 1 risk factor (P = 0.01 and P = 0.02). Similar results were obtained for EFS. Cox regression analysis showed an unfavourable MIPI to be the only independent predictor of shorter EFS. This retrospective study shows that stage-MIPI can be a reliable prognostic indicator for PIL of both low-grade MZL and diffuse large B-cell histology, enabling the early identification of patients at higher risk of failure.
KW - Diffuse large B-cell lymphoma (DLCL)
KW - Extranodal marginal zone B-cell lymphoma (MZL)
KW - Modified international prognostic index (MIPI)
KW - Primary intestinal lymphoma (PIL)
UR - http://www.scopus.com/inward/record.url?scp=0036067380&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036067380&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2141.2002.03613.x
DO - 10.1046/j.1365-2141.2002.03613.x
M3 - Article
VL - 118
SP - 218
EP - 228
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -