The modulation of skin irritation

E. Berardesca, F. Distante

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Irritant contact dermatitis (ICD) is a multifactorial disease, the onset and modulation of which depend on both endogenous and exogenous factors. Among the former, age, race, site, sex and history of dermatitis may all be important. Such variables can now readily be quantified by objective noninvasive techniques, such as measurement of transepidermal water loss (TEWL). Moreover, effects of irritants on the epidermis are related to the particular chemical properties of each molecule, contributing further to clinical heterogeneity. Release of cytokines and mediators may be initiated by a number of cells, including living keratinocytes and those of the stratum corneum, thus modulating inflammation and repair. Furthermore, differences in mechanisms of inflammation between acute and chronic ICD may exist, the former being characterized predominantly by inflammation, the latter by hyperproliferation and transient hyperkeratosis. These findings may explain the complexity and difficulty of investigating ICD. Better understanding and quantification of these mechanisms may lead to identification of high-risk individuals and more effective prevention and treatment.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalContact Dermatitis
Volume31
Issue number5
DOIs
Publication statusPublished - 1994

Fingerprint

Dermatitis
Irritant Dermatitis
Irritants
Contact Dermatitis
Skin
Modulation
Inflammation
Keratinocytes
Epidermis
Cornea
Cell Count
Chemical properties
Cytokines
Repair
Water
History
Molecules
Therapeutics

Keywords

  • Barrier function
  • Cytokines
  • Interferons
  • Irritant contact dermatitis
  • Skin lipids
  • SLS
  • TEWL

ASJC Scopus subject areas

  • Dermatology
  • Toxicology
  • Immunology

Cite this

The modulation of skin irritation. / Berardesca, E.; Distante, F.

In: Contact Dermatitis, Vol. 31, No. 5, 1994, p. 281-287.

Research output: Contribution to journalArticle

Berardesca, E & Distante, F 1994, 'The modulation of skin irritation', Contact Dermatitis, vol. 31, no. 5, pp. 281-287. https://doi.org/10.1111/j.1600-0536.1994.tb02019.x
Berardesca, E. ; Distante, F. / The modulation of skin irritation. In: Contact Dermatitis. 1994 ; Vol. 31, No. 5. pp. 281-287.
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