The molecular action of tumor necrosis factor-α

G. Camussi, E. Albano, C. Tetta, F. Bussolino

Research output: Contribution to journalArticle

226 Citations (Scopus)

Abstract

Tumor necrosis factor-α (TNF-α) is a polypeptide hormone newly synthesized by different cell types upon stimulation with endotoxin, inflammatory mediators (C5a anaphylatoxin), or cytokines such as interleukin-1 and, in an autocrine manner, TNF itself. The net biological effect of TNF-α may vary depending on relative concentration, duration of cell exposure and presence of other mediators which may act in synergism with this cytokine. TNF-α may be relevant either in pathological events occurring in cachexia and endotoxic shock and inflammation or in beneficial processes such as host defense, immunity and tissue homeostasis. The biological effects of TNF-α are triggered by the binding to specific cell surface receptors. The formation of TNF-α - receptor complex activates a variety of biochemical pathways that include the transduction of the signal at least in part controlled by guanine-nucleotide-binding regulatory proteins (G proteins), its amplification through activation of adenyl cyclase, phospholipases and protein kinases with the generation of second messenger pathways. The transduction of selected genes in different cell types determines the characteristics of the cell response to TNF-α. The full understanding of the molecular mechanisms of TNF-α will provide the basis for a pharmacological approach intended to inhibit or potentiate selected biological actions of this cytokine.

Original languageEnglish
Pages (from-to)3-14
Number of pages12
JournalEuropean Journal of Biochemistry
Volume202
Issue number1
Publication statusPublished - 1991

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Tumor Necrosis Factor-alpha
Cytokines
Tissue homeostasis
Anaphylatoxins
Cachexia
Guanine Nucleotides
Peptide Hormones
Phospholipases
Tumor Necrosis Factor Receptors
Cell Surface Receptors
Second Messenger Systems
Septic Shock
Interleukin-1
GTP-Binding Proteins
Adenylyl Cyclases
Endotoxins
Protein Kinases
Amplification
Immunity
Signal Transduction

ASJC Scopus subject areas

  • Biochemistry

Cite this

The molecular action of tumor necrosis factor-α. / Camussi, G.; Albano, E.; Tetta, C.; Bussolino, F.

In: European Journal of Biochemistry, Vol. 202, No. 1, 1991, p. 3-14.

Research output: Contribution to journalArticle

Camussi, G, Albano, E, Tetta, C & Bussolino, F 1991, 'The molecular action of tumor necrosis factor-α', European Journal of Biochemistry, vol. 202, no. 1, pp. 3-14.
Camussi, G. ; Albano, E. ; Tetta, C. ; Bussolino, F. / The molecular action of tumor necrosis factor-α. In: European Journal of Biochemistry. 1991 ; Vol. 202, No. 1. pp. 3-14.
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