The molecular changes driving the carcinogenesis in Barrett's esophagus: Which came first, the chicken or the egg?

A. Russo, G. Bronte, D. Cabibi, V. Bazan, G. Cicero, A. Bertani, S. Rizzo, E. Fiorentino

Research output: Contribution to journalArticle

Abstract

Esophageal adenocarcinoma originates from columnar metaplastic epithelium of the distal esophagus. Various steps for this carcinogenetic process are known. Before the onset of high-grade dysplasia and adenocarcinoma, endoscopic surveillance is possible. However, because of the high cost of long-term surveillance, predictive factors for cancer are being evaluated to identify subjects with metaplasia who have a higher risk of developing malignancy. Molecular changes seem suitable for this purpose, but could require a high resource expenditure. While trying to identify the best predictive factors for cancer risk, molecular changes and differences in miRNA expression profile between the various steps leading to cancer could help to clarify Barrett's carcinogenesis. In this attempt to find a molecular explanation for the onset of esophageal adenocarcinoma, it is still difficult to understand whether the molecular changes are causes or effects of the neoplastic phenotypic modifications.

Original languageEnglish
Pages (from-to)278-289
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Volume86
Issue number3
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Adenocarcinoma
  • Barrett's esophagus
  • Dysplasia
  • Endoscopic surveillance
  • Metaplasia
  • MiRNAs

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

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