The molecular interaction between the glutamatergic, noradrenergic, dopaminergic and serotoninergic systems informs a detailed genetic perspective on depressive phenotypes

Antonio Drago, Concetta Crisafulli, Antonina Sidoti, Alessandro Serretti

Research output: Contribution to journalArticlepeer-review

Abstract

The glutamatergic pathway has been consistently involved in the physiopathology of depressive disorder. However a complete dissection and integration of its role in the context of other known mechanisms is lacking. We summarized and integrated the evidence of various levels of interaction between glutamatergic and monoaminergic pathways (see videos). We identified six molecular pathways, some of which with specific regional distribution within the brain. From the six pathways we identified the key proteins and their coding genes, we then provided a detailed list of possible candidates with practical suggestions for association studies planning.

Original languageEnglish
Pages (from-to)418-460
Number of pages43
JournalProgress in Neurobiology
Volume94
Issue number4
DOIs
Publication statusPublished - Sep 1 2011

Keywords

  • Candidate gene
  • Glutamate
  • Major depression
  • Monoaminergic
  • Variation

ASJC Scopus subject areas

  • Neuroscience(all)

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