The molecular mechanism of B cell activation by toll-like receptor protein RP-105

Vivien W F Chan, Ingrid Mecklenbräuker, I. Hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky

Research output: Contribution to journalArticle

Abstract

The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C β I/II (PKC[βI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalJournal of Experimental Medicine
Volume188
Issue number1
DOIs
Publication statusPublished - Jul 6 1998

Fingerprint

Toll-Like Receptors
B-Lymphocytes
src-Family Kinases
Antigen Receptors
Proteins
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
Innate Immunity
Protein Kinase C
Immunoglobulins
Cell Proliferation
Membranes

Keywords

  • B lymphocytes
  • Mice
  • RP-105
  • Signal transduction

ASJC Scopus subject areas

  • Immunology

Cite this

Chan, V. W. F., Mecklenbräuker, I., Su, I. H., Texido, G., Leitges, M., Carsetti, R., ... Tarakhovsky, A. (1998). The molecular mechanism of B cell activation by toll-like receptor protein RP-105. Journal of Experimental Medicine, 188(1), 93-101. https://doi.org/10.1084/jem.188.1.93

The molecular mechanism of B cell activation by toll-like receptor protein RP-105. / Chan, Vivien W F; Mecklenbräuker, Ingrid; Su, I. Hsin; Texido, Gemma; Leitges, Michael; Carsetti, Rita; Lowell, Clifford A.; Rajewsky, Klaus; Miyake, Kensuke; Tarakhovsky, Alexander.

In: Journal of Experimental Medicine, Vol. 188, No. 1, 06.07.1998, p. 93-101.

Research output: Contribution to journalArticle

Chan, VWF, Mecklenbräuker, I, Su, IH, Texido, G, Leitges, M, Carsetti, R, Lowell, CA, Rajewsky, K, Miyake, K & Tarakhovsky, A 1998, 'The molecular mechanism of B cell activation by toll-like receptor protein RP-105', Journal of Experimental Medicine, vol. 188, no. 1, pp. 93-101. https://doi.org/10.1084/jem.188.1.93
Chan, Vivien W F ; Mecklenbräuker, Ingrid ; Su, I. Hsin ; Texido, Gemma ; Leitges, Michael ; Carsetti, Rita ; Lowell, Clifford A. ; Rajewsky, Klaus ; Miyake, Kensuke ; Tarakhovsky, Alexander. / The molecular mechanism of B cell activation by toll-like receptor protein RP-105. In: Journal of Experimental Medicine. 1998 ; Vol. 188, No. 1. pp. 93-101.
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