The molecular mechanism of B cell activation by toll-like receptor protein RP-105

Vivien W F Chan, Ingrid Mecklenbräuker, I. Hsin Su, Gemma Texido, Michael Leitges, Rita Carsetti, Clifford A. Lowell, Klaus Rajewsky, Kensuke Miyake, Alexander Tarakhovsky

Research output: Contribution to journalArticlepeer-review

Abstract

The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C β I/II (PKC[βI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation.

Original languageEnglish
Pages (from-to)93-101
Number of pages9
JournalJournal of Experimental Medicine
Volume188
Issue number1
DOIs
Publication statusPublished - Jul 6 1998

Keywords

  • B lymphocytes
  • Mice
  • RP-105
  • Signal transduction

ASJC Scopus subject areas

  • Immunology

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