Abstract
Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.
| Original language | English |
|---|---|
| Journal | Medical Science Monitor |
| Volume | 15 |
| Issue number | 11 |
| Publication status | Published - Nov 2009 |
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Keywords
- Coenzyme Q-Ter®
- Hearing loss
- Noise
- Otoacoustic emissions
- Oxidative stress markers
ASJC Scopus subject areas
- Medicine(all)
Cite this
The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects : A pilot study. / Fetoni, Anna Rita; Garzaro, Massimiliano; Ralli, Massimo; Landolfo, Vincenzo; Sensini, Matteo; Pecorari, Giancarlo; Mordente, Alvaro; Paludetti, Gaetano; Giordano, Carlo.
In: Medical Science Monitor, Vol. 15, No. 11, 11.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects
T2 - A pilot study
AU - Fetoni, Anna Rita
AU - Garzaro, Massimiliano
AU - Ralli, Massimo
AU - Landolfo, Vincenzo
AU - Sensini, Matteo
AU - Pecorari, Giancarlo
AU - Mordente, Alvaro
AU - Paludetti, Gaetano
AU - Giordano, Carlo
PY - 2009/11
Y1 - 2009/11
N2 - Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.
AB - Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.
KW - Coenzyme Q-Ter®
KW - Hearing loss
KW - Noise
KW - Otoacoustic emissions
KW - Oxidative stress markers
UR - http://www.scopus.com/inward/record.url?scp=71649085296&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=71649085296&partnerID=8YFLogxK
M3 - Article
C2 - 19865065
AN - SCOPUS:71649085296
VL - 15
JO - Medical Science Monitor
JF - Medical Science Monitor
SN - 1234-1010
IS - 11
ER -