The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: A pilot study

Anna Rita Fetoni, Massimiliano Garzaro, Massimo Ralli, Vincenzo Landolfo, Matteo Sensini, Giancarlo Pecorari, Alvaro Mordente, Gaetano Paludetti, Carlo Giordano

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.

Original languageEnglish
JournalMedical Science Monitor
Volume15
Issue number11
Publication statusPublished - Nov 2009

Fingerprint

coenzyme Q10
Noise
Oxidative Stress
Antioxidants
Placebos
Pure-Tone Audiometry
Cochlea
Volunteers
Appointments and Schedules
Pharmacology
Therapeutics

Keywords

  • Coenzyme Q-Ter®
  • Hearing loss
  • Noise
  • Otoacoustic emissions
  • Oxidative stress markers

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects : A pilot study. / Fetoni, Anna Rita; Garzaro, Massimiliano; Ralli, Massimo; Landolfo, Vincenzo; Sensini, Matteo; Pecorari, Giancarlo; Mordente, Alvaro; Paludetti, Gaetano; Giordano, Carlo.

In: Medical Science Monitor, Vol. 15, No. 11, 11.2009.

Research output: Contribution to journalArticle

Fetoni, AR, Garzaro, M, Ralli, M, Landolfo, V, Sensini, M, Pecorari, G, Mordente, A, Paludetti, G & Giordano, C 2009, 'The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: A pilot study', Medical Science Monitor, vol. 15, no. 11.
Fetoni, Anna Rita ; Garzaro, Massimiliano ; Ralli, Massimo ; Landolfo, Vincenzo ; Sensini, Matteo ; Pecorari, Giancarlo ; Mordente, Alvaro ; Paludetti, Gaetano ; Giordano, Carlo. / The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects : A pilot study. In: Medical Science Monitor. 2009 ; Vol. 15, No. 11.
@article{ed386f6375cf48d9891da596b8756b0f,
title = "The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects: A pilot study",
abstract = "Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer{\circledR}), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter{\circledR} (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter{\circledR} and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter{\circledR} and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.",
keywords = "Coenzyme Q-Ter{\circledR}, Hearing loss, Noise, Otoacoustic emissions, Oxidative stress markers",
author = "Fetoni, {Anna Rita} and Massimiliano Garzaro and Massimo Ralli and Vincenzo Landolfo and Matteo Sensini and Giancarlo Pecorari and Alvaro Mordente and Gaetano Paludetti and Carlo Giordano",
year = "2009",
month = "11",
language = "English",
volume = "15",
journal = "Medical Science Monitor",
issn = "1234-1010",
publisher = "International Scientific Literature Inc.",
number = "11",

}

TY - JOUR

T1 - The monitoring role of otoacoustic emissions and oxidative stress markers in the protective effects of antioxidant administration in noise-exposed subjects

T2 - A pilot study

AU - Fetoni, Anna Rita

AU - Garzaro, Massimiliano

AU - Ralli, Massimo

AU - Landolfo, Vincenzo

AU - Sensini, Matteo

AU - Pecorari, Giancarlo

AU - Mordente, Alvaro

AU - Paludetti, Gaetano

AU - Giordano, Carlo

PY - 2009/11

Y1 - 2009/11

N2 - Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.

AB - Background: Oxidative stress has been recently identified as the pivotal pathway of cochlear damage. The aims of this study were to evaluate whether distortion product otoacoustic emissions (DPOAEs) can discriminate normal subjects with a risk of damage induced by sound exposure, the effectiveness of OAEs in monitoring the protective effects of Coenzyme Q10 terclatrate (QTer®), and the role of blood parameters in monitoring preventive therapies. Material/Methods: Twenty volunteers were randomized to two groups: the first (n=10) was treated with Q-Ter® (200 mg orally once daily) for 7 days before noise exposure and the second group was treated with placebo using the same schedule. All participants were exposed to white noise of 90 dB HL for 15 minutes. DPOAEs and pure-tone audiometry (PTA) were measured before and 1 h, 16 h, and 7 and 21 days after exposure. Inflammatory and oxidative stress parameters were measured before and 2 and 24 h after exposure. Results: In the placebo group, DPOAE amplitudes were reduced 1 and 16 h after exposure compared with the baseline values (p0.1). PTA threshold values in the Q-Ter® and placebo groups did not differ before and after exposure. No significantly different levels of the inflammatory markers were observed in the Q-Ter® and placebo groups at the different time points. Conclusions: This pilot study confirms that DPOAEs represent a sensitive test for monitoring the effects of noise in preclinical conditions and pharmacological treatment.

KW - Coenzyme Q-Ter®

KW - Hearing loss

KW - Noise

KW - Otoacoustic emissions

KW - Oxidative stress markers

UR - http://www.scopus.com/inward/record.url?scp=71649085296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=71649085296&partnerID=8YFLogxK

M3 - Article

C2 - 19865065

AN - SCOPUS:71649085296

VL - 15

JO - Medical Science Monitor

JF - Medical Science Monitor

SN - 1234-1010

IS - 11

ER -