The monocyte chemotactic protein 1 (MCP-1) and interleukin 8 (IL-8) in Hodgkin's disease and in solid tumours

M. G. Luciani, A. Stoppacciaro, G. Peri, A. Mantovani, L. P. Ruco

Research output: Contribution to journalArticle

Abstract

Aims - Monocyte chemotactic protein 1 (MCP-1) and interleukin 8 (IL-8) are small, inducible proteins with chemotactic activity for specific subsets of leucocytes. The possibility that MCP-1 and IL-8 are produced in tissues involved by Hodgkin's disease, thus contributing to the inflammatory-type background of the lesion, was investigated. Methods - The presence of RNA transcripts for MCP-1 and IL-8 was investigated in biopsy samples of 24 cases of Hodgkin's disease, 17 non-Hodgkin's malignant lymphomas, 30 solid tumours, and 30 histologically normal tissues by means of reverse transcription- polymerase chain reaction (RT-PCR)/Southern blot analysis. Results - MCP-1 expression was detected in 23 of 24 cases of Hodgkin's disease, in seven of 17 cases of B cell non-Hodgkin's lymphoma, and in seven of 14 cases of reactive lymphoid hyperplasia. IL-8 was present in six of 14 cases of Hodgkin's disease, and was seen only rarely in B cell non-Hodgkin's lymphoma and in reactive lymphoid tissues. MCP-1 and IL-8 RNA transcripts were detected in 13 of 25 carcinomas originating from the lung, breast, thyroid, and ovary. Conclusions - These findings are consistent with the possibility that MCP-1 and IL-8 are two additional cytokines involved in the pathogenesis of Hodgkin's disease.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalJournal of Clinical Pathology
Volume51
Issue number5
Publication statusPublished - 1998

Keywords

  • Hodgkin's disease
  • Interleukin 8
  • Monocyte chemotactic protein 1
  • Solid tumours

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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