The morpho-functional organization of secretory traffic. Here today, where tomorrow?

Alberto Luini, Alexander A. Mironov, Maria Antonietta De Matteis, Gareth Griffiths

Research output: Contribution to journalArticlepeer-review


The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.

Original languageEnglish
Pages (from-to)29-54
Number of pages26
JournalMedicina nei secoli
Issue number1
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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