TY - JOUR
T1 - The morpho-functional organization of secretory traffic. Here today, where tomorrow?
AU - Luini, Alberto
AU - Mironov, Alexander A.
AU - De Matteis, Maria Antonietta
AU - Griffiths, Gareth
PY - 2007
Y1 - 2007
N2 - The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.
AB - The morpho-functional principles of secretory traffic are still unclear, in stark contrast with our advanced knowledge of the underlying molecular machineries. Recently, the conceptual and technological hindrances that have delayed progress in this area have been disappearing, and new glimpses of the organization of traffic in intact cells are being revealed by a cluster of powerful morphological techniques. Here, we discuss the new advances in the light of the three main possible traffic principles: by anterograde vesicles, progression/maturation, and flow via continuities.
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M3 - Article
C2 - 18447166
AN - SCOPUS:44449172071
VL - 19
SP - 29
EP - 54
JO - Medicina nei secoli
JF - Medicina nei secoli
SN - 0394-9001
IS - 1
ER -