The MPTP mouse model: Cues on DA release and neural stem cell restorative role

Pier Andrea Serra, Stefano Pluchino, Bianca Marchetti, Maria S. Desole, Egidio Miele

Research output: Contribution to journalArticlepeer-review

Abstract

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to cause parkinsonism in humans and this fact is a major incentive for using this toxin as an animal model to study the pathogenesis of Parkinson's disease (PD). Although the monkey MPTP model remains the best, most studies have been performed in mice. The so-called acute and sub-acute regimens are commonly used. Both induce tissue striatal dopamine (DA) depletion and nigral neuron death. Tissue striatal DA depletion does not necessarily correlate with impairment of striatal dopaminergic functioning. In freely moving mice, systemic acute or sub-acute MPTP directly induces prolonged release of striatal DA. Such DA release may be considered the first step in MPTP-induced striatal DA depletion. Reportedly, neural stem cells improve symptoms in the MPTP model of PD by interacting with the MPTP-induced pathological nigrostriatal milieu.

Original languageEnglish
JournalParkinsonism and Related Disorders
Volume14
Issue numberSUPPL.2
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Microdialysis
  • Mouse striatum
  • MPTP
  • Neural stem cells
  • Parkinson's disease

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Neurology

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