The M/SAR elements of the bithorax complex in Drosophila melanogaster

T. V. Boykova, V. Orlando, R. Lpo, S. S. Bogachev

Research output: Contribution to journalArticle

Abstract

The bithorax (BX) complex of Drosophila is a complex polygenic region with a multifactorial system of regulation. One of the levels of the regulatory system of the BX complex is its association with the nuclear skeleton structures through a specific interaction of the M/SAR DNA with the nuclear matrix proteins. In the present work, M/SAR elements were mapped on the molecular-genetic map of the region. All of the elements examined were found to colocalize with regulatory elements and form clusters that restrict/bracket the genetically active domains. All M/SAR DNA revealed was shown to bins specifically to the purified Drosophila melanogaster lamin.

Original languageEnglish
Pages (from-to)1467-1479
Number of pages13
JournalGenetika
Volume41
Issue number11
Publication statusPublished - 2005

ASJC Scopus subject areas

  • Genetics

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    Boykova, T. V., Orlando, V., Lpo, R., & Bogachev, S. S. (2005). The M/SAR elements of the bithorax complex in Drosophila melanogaster. Genetika, 41(11), 1467-1479.