We searched for the mtDNA A3243G mutation ("MELAS" mutation) in 46 migraneurs with or without aura presenting positive family history in the maternal lineage. The goal of the study was to confirm the determine the role of an oxidative-phosphorilation disfunction in the pathogenesis of some type of migraine and to verify whether migraine is a monosintomatic form of the MELAS syndrome. We did not find the A3243G mutation in any of our patients. These results suggest that there is no association between migraine and mutation of mtDNA.
|Translated title of the contribution||The mtDNA A3243G mutation is not frequent in Migraineurs|
|Number of pages||5|
|Publication status||Published - 2000|
ASJC Scopus subject areas
- Clinical Neurology