The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection

Eleonora Castelletti; Sergio Lo Caputo; Louise Kuhn; Manuela Borelli; Johanna Gajardo; Moses Sinkala; Daria Trabattoni; Chipepo Kankasa; Eleonora Lauri; Alberto Clivio; Luca Piacentini; Dorothy H. Bray; Grace M. Aldrovandi; Donald M. Thea; Francisco Veas; Manuela Nebuloni; Francesco Mazzotta; Mario Clerici

doi:10.1371/journal.pone.0000969

The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection

Eleonora Castelletti, Sergio Lo Caputo, Louise Kuhn, Manuela Borelli, Johanna Gajardo, Moses Sinkala, Daria Trabattoni, Chipepo Kankasa, Eleonora Lauri, Alberto Clivio, Luca Piacentini, Dorothy H. Bray, Grace M. Aldrovandi, Donald M. Thea, Francisco Veas, Manuela Nebuloni, Francesco Mazzotta, Mario Clerici

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Background. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propia (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. Methodology/Findings. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were, increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. Conclusion. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.

Original language	English
Article number	e969
Journal	PLoS One
Volume	2
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0000969
Publication status	Published - Oct 3 2007

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Castelletti, E., Caputo, S. L., Kuhn, L., Borelli, M., Gajardo, J., Sinkala, M., Trabattoni, D., Kankasa, C., Lauri, E., Clivio, A., Piacentini, L., Bray, D. H., Aldrovandi, G. M., Thea, D. M., Veas, F., Nebuloni, M., Mazzotta, F., & Clerici, M. (2007). The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. PLoS One, 2(10), [e969]. https://doi.org/10.1371/journal.pone.0000969

The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. / Castelletti, Eleonora; Caputo, Sergio Lo; Kuhn, Louise; Borelli, Manuela; Gajardo, Johanna; Sinkala, Moses; Trabattoni, Daria; Kankasa, Chipepo; Lauri, Eleonora; Clivio, Alberto; Piacentini, Luca; Bray, Dorothy H.; Aldrovandi, Grace M.; Thea, Donald M.; Veas, Francisco; Nebuloni, Manuela; Mazzotta, Francesco; Clerici, Mario.

In: PLoS One, Vol. 2, No. 10, e969, 03.10.2007.

Research output: Contribution to journal › Article › peer-review

Castelletti, E, Caputo, SL, Kuhn, L, Borelli, M, Gajardo, J, Sinkala, M, Trabattoni, D, Kankasa, C, Lauri, E, Clivio, A, Piacentini, L, Bray, DH, Aldrovandi, GM, Thea, DM, Veas, F, Nebuloni, M, Mazzotta, F & Clerici, M 2007, 'The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection', PLoS One, vol. 2, no. 10, e969. https://doi.org/10.1371/journal.pone.0000969

Castelletti, Eleonora ; Caputo, Sergio Lo ; Kuhn, Louise ; Borelli, Manuela ; Gajardo, Johanna ; Sinkala, Moses ; Trabattoni, Daria ; Kankasa, Chipepo ; Lauri, Eleonora ; Clivio, Alberto ; Piacentini, Luca ; Bray, Dorothy H. ; Aldrovandi, Grace M. ; Thea, Donald M. ; Veas, Francisco ; Nebuloni, Manuela ; Mazzotta, Francesco ; Clerici, Mario. / The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection. In: PLoS One. 2007 ; Vol. 2, No. 10.

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abstract = "Background. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propia (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. Methodology/Findings. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were, increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. Conclusion. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.",

author = "Eleonora Castelletti and Caputo, {Sergio Lo} and Louise Kuhn and Manuela Borelli and Johanna Gajardo and Moses Sinkala and Daria Trabattoni and Chipepo Kankasa and Eleonora Lauri and Alberto Clivio and Luca Piacentini and Bray, {Dorothy H.} and Aldrovandi, {Grace M.} and Thea, {Donald M.} and Francisco Veas and Manuela Nebuloni and Francesco Mazzotta and Mario Clerici",

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AU - Borelli, Manuela

AU - Gajardo, Johanna

AU - Sinkala, Moses

AU - Trabattoni, Daria

AU - Kankasa, Chipepo

AU - Lauri, Eleonora

AU - Clivio, Alberto

AU - Piacentini, Luca

AU - Bray, Dorothy H.

AU - Aldrovandi, Grace M.

AU - Thea, Donald M.

AU - Veas, Francisco

AU - Nebuloni, Manuela

AU - Mazzotta, Francesco

AU - Clerici, Mario

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N2 - Background. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propia (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. Methodology/Findings. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were, increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. Conclusion. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.

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