TY - JOUR
T1 - The mucosae-associated epithelial chemokine (MEC/CCL28) modulates immunity in HIV infection
AU - Castelletti, Eleonora
AU - Caputo, Sergio Lo
AU - Kuhn, Louise
AU - Borelli, Manuela
AU - Gajardo, Johanna
AU - Sinkala, Moses
AU - Trabattoni, Daria
AU - Kankasa, Chipepo
AU - Lauri, Eleonora
AU - Clivio, Alberto
AU - Piacentini, Luca
AU - Bray, Dorothy H.
AU - Aldrovandi, Grace M.
AU - Thea, Donald M.
AU - Veas, Francisco
AU - Nebuloni, Manuela
AU - Mazzotta, Francesco
AU - Clerici, Mario
PY - 2007/10/3
Y1 - 2007/10/3
N2 - Background. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propia (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. Methodology/Findings. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were, increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. Conclusion. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.
AB - Background. CCL28 (MEC) binds to CCR3 and CCR10 and recruits IgA-secreting plasma cells (IgA-ASC) in the mucosal lamina propia (MLP). Mucosal HIV-specific IgA are detected in HIV-infection and exposure. The CCL28 circuit was analyzed in HIV-infected and-exposed individuals and in HIV-unexposed controls; the effect of CCL28 administration on gastrointestinal MLP IgA-ASC was verified in a mouse model. Methodology/Findings. CCL28 was augmented in breast milk (BM) plasma and saliva of HIV-infected and -exposed individuals; CCR3+ and CCR10+ B lymphocytes were, increased in these same individuals. Additionally: 1) CCL28 concentration in BM was associated with longer survival in HIV vertically-infected children; and 2) gastro-intestinal mucosal IgA-ASC were significantly increased in VSV-immunized mice receiving CCL28. Conclusion. CCL28 mediates mucosal immunity in HIV exposure and infection. CCL28-including constructs should be considered in mucosal vaccines to prevent HIV infection of the gastro-intestinal MLP via modulation of IgA-ASC.
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U2 - 10.1371/journal.pone.0000969
DO - 10.1371/journal.pone.0000969
M3 - Article
C2 - 17912348
AN - SCOPUS:41449111647
VL - 2
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 10
M1 - e969
ER -