The multifaceted functions of exosomes in health and disease: An overview

Claudia Arenaccio, Maurizio Federico

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Exosomes are extracellular vesicles of 50–150 nm in diameter secreted by basically all cell types. They mediate micro-communication among cells, tissues, and organs under both healthy and disease conditions by virtue of their ability to deliver macromolecules to target cells. Research on exosomes is a rapidly growing field, however many aspects of their biogenesis and functions still await a complete clarification. In our review we summarize most recent findings regarding biogenesis, structure, and functions of exosomes. In addition, an overview regarding the role of exosomes in both infectious and non-infectious diseases is provided. Finally, the use of exosomes as biomarkers and delivery tools for therapeutic molecules is addressed. Considering the body of literature data, exosomes have to be considered key components of the intercellular communication in both health and disease.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages3-19
Number of pages17
DOIs
Publication statusPublished - Jan 1 2017

Publication series

NameAdvances in Experimental Medicine and Biology
Volume998
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Exosomes
  • Extracellular vesicles
  • Intraluminal vesicles
  • Multivesicular bodies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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