The multifaceted mitochondrion

An attractive candidate for therapeutic strategies

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments.

Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalPharmacological Research
Volume99
DOIs
Publication statusPublished - Sep 3 2015

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Mitochondria
Mitochondrial Dynamics
Mitochondrial Diseases
Quality Control
Therapeutics
Pharmacology

Keywords

  • Mitochondrial biogenesis
  • Mitochondrial plasticity
  • Mitochondrial quality control

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments.",
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AB - Mitochondria are considered the powerhouse of the cell and disturbances in mitochondrial functions are involved in several disorders such as neurodegeneration and mitochondrial diseases. This review summarizes pharmacological strategies that aim at modifying the number of mitochondria, their dynamics or the mitochondrial quality-control mechanisms, in several pathological instances in which any of these mechanisms are impaired or abnormal. The interplay between different cellular pathways that involve mitochondria in order to respond to stress is highlighted. Such a high mitochondrial plasticity could be exploited for new treatments.

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