The multifaceted relationship between IL-10 and adaptive immunity: Putting together the pieces of a puzzle

Simone Mocellin; Francesco Marincola; Carlo Riccardo Rossi; Donato Nitti; Mario Lise

doi:10.1016/j.cytogfr.2003.11.001

The multifaceted relationship between IL-10 and adaptive immunity: Putting together the pieces of a puzzle

Simone Mocellin, Francesco Marincola, Carlo Riccardo Rossi, Donato Nitti, Mario Lise

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive immunity-related cells. Although generally considered an immunosuppressive molecule, IL-10 possesses immunostimulatory properties in several in vitro and in vivo models. These very different outcomes are believed to depend upon experimental conditions, the dominant immune effector mediating a given immune response, the timing of IL-10 production/administration, and IL-10 dose and/or location of expression. In the present work, we review the current knowledge regarding IL-10 activity on adaptive immunity related cells, emphasize new insights on IL-10 molecular/cellular targets, and summarize the available data on the relationship between IL-10 and some pathological conditions (e.g. infectious diseases, autoimmunity, allergy, cancer and transplantation) involving adaptive immunity.

Original language	English
Pages (from-to)	61-76
Number of pages	16
Journal	Cytokine and Growth Factor Reviews
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.cytogfr.2003.11.001
Publication status	Published - Feb 2004

Keywords

Adaptive immunity
Cytotoxic T lymphocyte
IL-10

ASJC Scopus subject areas

Immunology
Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Biochemistry, Genetics and Molecular Biology(all)

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