The multifaceted relationship between IL-10 and adaptive immunity: Putting together the pieces of a puzzle

Simone Mocellin, Francesco Marincola, Carlo Riccardo Rossi, Donato Nitti, Mario Lise

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive immunity-related cells. Although generally considered an immunosuppressive molecule, IL-10 possesses immunostimulatory properties in several in vitro and in vivo models. These very different outcomes are believed to depend upon experimental conditions, the dominant immune effector mediating a given immune response, the timing of IL-10 production/administration, and IL-10 dose and/or location of expression. In the present work, we review the current knowledge regarding IL-10 activity on adaptive immunity related cells, emphasize new insights on IL-10 molecular/cellular targets, and summarize the available data on the relationship between IL-10 and some pathological conditions (e.g. infectious diseases, autoimmunity, allergy, cancer and transplantation) involving adaptive immunity.

Original languageEnglish
Pages (from-to)61-76
Number of pages16
JournalCytokine and Growth Factor Reviews
Volume15
Issue number1
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Adaptive immunity
  • Cytotoxic T lymphocyte
  • IL-10

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

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