The multifaceted role of glial cells in amyotrophic lateral sclerosis

Chiara F. Valori, Liliana Brambilla, Francesca Martorana, Daniela Rossi

Research output: Contribution to journalArticle

Abstract

Despite indisputable progress in the molecular and genetic aspects of amyotrophic lateral sclerosis (ALS), a mechanistic comprehension of the neurodegenerative processes typical of this disorder is still missing and no effective cures to halt the progression of this pathology have yet been developed. Therefore, it seems that a substantial improvement of the outcome of ALS treatments may depend on a better understanding of the molecular mechanisms underlying neuronal pathology and survival as well as on the establishment of novel etiological therapeutic strategies. Noteworthy, a convergence of recent data from multiple studies suggests that, in cellular and animal models of ALS, a complex pathological interplay subsists between motor neurons and their non-neuronal neighbours, particularly glial cells. These observations not only have drawn attention to the physiopathological changes glial cells undergo during ALS progression, but they have moved the focus of the investigations from intrinsic defects and weakening of motor neurons to glia-neuron interactions. In this review, we summarize the growing body of evidence supporting the concept that different glial populations are critically involved in the dreadful chain of events leading to motor neuron sufferance and death in various forms of ALS. The outlined observations strongly suggest that glial cells can be the targets for novel therapeutic interventions in ALS.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalCellular and Molecular Life Sciences
Volume71
Issue number2
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Amyotrophic lateral sclerosis
  • Astrocytes
  • Glia
  • Microglia
  • Neurodegeneration
  • Transgenic animals

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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