TY - JOUR
T1 - The multifaceted role of lysine acetylation in cancer
T2 - Prognostic biomarker and therapeutic target
AU - Di Martile, Marta
AU - Del Bufalo, Donatella
AU - Trisciuoglio, Daniela
PY - 2016
Y1 - 2016
N2 - Lysine acetylation is a post-translational modification that regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. Recently, several reports have demonstrated that numerous cytosolic proteins are also acetylated and that this modification, affecting protein activity, localization and stability has profound consequences on their cellular functions. Interestingly, most non-histone proteins targeted by acetylation are relevant for tumorigenesis. In this review, we will analyze the functional implications of lysine acetylation in different cellular compartments, and will examine our current understanding of lysine acetyltransferases family, highlighting the biological role and prognostic value of these enzymes and their substrates in cancer. The latter part of the article will address challenges and current status of molecules targeting lysine acetyltransferase enzymes in cancer therapy.
AB - Lysine acetylation is a post-translational modification that regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. Recently, several reports have demonstrated that numerous cytosolic proteins are also acetylated and that this modification, affecting protein activity, localization and stability has profound consequences on their cellular functions. Interestingly, most non-histone proteins targeted by acetylation are relevant for tumorigenesis. In this review, we will analyze the functional implications of lysine acetylation in different cellular compartments, and will examine our current understanding of lysine acetyltransferases family, highlighting the biological role and prognostic value of these enzymes and their substrates in cancer. The latter part of the article will address challenges and current status of molecules targeting lysine acetyltransferase enzymes in cancer therapy.
KW - Cancer
KW - KAT inhibitors
KW - Lysine acetylation
KW - Lysine acetyltransferases
UR - http://www.scopus.com/inward/record.url?scp=84983542242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983542242&partnerID=8YFLogxK
U2 - 10.18632/oncotarget.10048
DO - 10.18632/oncotarget.10048
M3 - Article
AN - SCOPUS:84983542242
VL - 7
SP - 55789
EP - 55810
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 34
ER -