The multifaceted role of lysine acetylation in cancer: Prognostic biomarker and therapeutic target

Marta Di Martile, Donatella Del Bufalo, Daniela Trisciuoglio

Research output: Contribution to journalArticle

Abstract

Lysine acetylation is a post-translational modification that regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. Recently, several reports have demonstrated that numerous cytosolic proteins are also acetylated and that this modification, affecting protein activity, localization and stability has profound consequences on their cellular functions. Interestingly, most non-histone proteins targeted by acetylation are relevant for tumorigenesis. In this review, we will analyze the functional implications of lysine acetylation in different cellular compartments, and will examine our current understanding of lysine acetyltransferases family, highlighting the biological role and prognostic value of these enzymes and their substrates in cancer. The latter part of the article will address challenges and current status of molecules targeting lysine acetyltransferase enzymes in cancer therapy.

Original languageEnglish
Pages (from-to)55789-55810
Number of pages22
JournalOncotarget
Volume7
Issue number34
DOIs
Publication statusPublished - 2016

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Keywords

  • Cancer
  • KAT inhibitors
  • Lysine acetylation
  • Lysine acetyltransferases

ASJC Scopus subject areas

  • Oncology

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