The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation

Katia Aquilano, Daniele Lettieri Barbato, Maria Rosa Ciriolo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nitric oxide (NO) is physiologically synthetized by a family of enzymes called NO synthases (NOSs). NO is a pleiotropic second messenger having a fundamental role in several cellular processes including cell differentiation. Being a high reactive molecule, NO must be synthetized in close proximity to the effector/target. For this reason, the subcellular localization of NOSs is tightly regulated by different post-translation mechanisms. Recently, in murine C2C12 myoblasts, we have demonstrated that mitochondrial biogenesis, an essential event for cell differentiation, can be effective only if the site of NO production is located at nuclear level, where NO favors the CREB-dependent expression of PGC-1a gene. The increase of NO flux in nuclei is elicited by the up-regulation and redistribution of neuronal NOS (nNOS) toward nuclei.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalCommunicative and Integrative Biology
Volume8
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Organelle Biogenesis
nitric oxide synthase
Nitric Oxide Synthase
cell differentiation
nitric oxide
Cell Differentiation
Nitric Oxide
myoblasts
Myoblasts
second messengers
Second Messenger Systems
translation (genetics)
biogenesis
Up-Regulation
mice
Enzymes
enzymes
Genes
genes

Keywords

  • Adipogenesis
  • Adipose tissue
  • Mitochondria
  • Myogenesis
  • Skeletal muscle

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation. / Aquilano, Katia; Barbato, Daniele Lettieri; Ciriolo, Maria Rosa.

In: Communicative and Integrative Biology, Vol. 8, No. 2, 2015, p. 1-4.

Research output: Contribution to journalArticle

@article{cd03236d019144c0ab3f1ae1dad90fe9,
title = "The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation",
abstract = "Nitric oxide (NO) is physiologically synthetized by a family of enzymes called NO synthases (NOSs). NO is a pleiotropic second messenger having a fundamental role in several cellular processes including cell differentiation. Being a high reactive molecule, NO must be synthetized in close proximity to the effector/target. For this reason, the subcellular localization of NOSs is tightly regulated by different post-translation mechanisms. Recently, in murine C2C12 myoblasts, we have demonstrated that mitochondrial biogenesis, an essential event for cell differentiation, can be effective only if the site of NO production is located at nuclear level, where NO favors the CREB-dependent expression of PGC-1a gene. The increase of NO flux in nuclei is elicited by the up-regulation and redistribution of neuronal NOS (nNOS) toward nuclei.",
keywords = "Adipogenesis, Adipose tissue, Mitochondria, Myogenesis, Skeletal muscle",
author = "Katia Aquilano and Barbato, {Daniele Lettieri} and Ciriolo, {Maria Rosa}",
year = "2015",
doi = "10.1080/19420889.2015.1017158",
language = "English",
volume = "8",
pages = "1--4",
journal = "Communicative and Integrative Biology",
issn = "1942-0889",
publisher = "Landes Bioscience",
number = "2",

}

TY - JOUR

T1 - The multifaceted role of nitric oxide synthases in mitochondrial biogenesis and cell differentiation

AU - Aquilano, Katia

AU - Barbato, Daniele Lettieri

AU - Ciriolo, Maria Rosa

PY - 2015

Y1 - 2015

N2 - Nitric oxide (NO) is physiologically synthetized by a family of enzymes called NO synthases (NOSs). NO is a pleiotropic second messenger having a fundamental role in several cellular processes including cell differentiation. Being a high reactive molecule, NO must be synthetized in close proximity to the effector/target. For this reason, the subcellular localization of NOSs is tightly regulated by different post-translation mechanisms. Recently, in murine C2C12 myoblasts, we have demonstrated that mitochondrial biogenesis, an essential event for cell differentiation, can be effective only if the site of NO production is located at nuclear level, where NO favors the CREB-dependent expression of PGC-1a gene. The increase of NO flux in nuclei is elicited by the up-regulation and redistribution of neuronal NOS (nNOS) toward nuclei.

AB - Nitric oxide (NO) is physiologically synthetized by a family of enzymes called NO synthases (NOSs). NO is a pleiotropic second messenger having a fundamental role in several cellular processes including cell differentiation. Being a high reactive molecule, NO must be synthetized in close proximity to the effector/target. For this reason, the subcellular localization of NOSs is tightly regulated by different post-translation mechanisms. Recently, in murine C2C12 myoblasts, we have demonstrated that mitochondrial biogenesis, an essential event for cell differentiation, can be effective only if the site of NO production is located at nuclear level, where NO favors the CREB-dependent expression of PGC-1a gene. The increase of NO flux in nuclei is elicited by the up-regulation and redistribution of neuronal NOS (nNOS) toward nuclei.

KW - Adipogenesis

KW - Adipose tissue

KW - Mitochondria

KW - Myogenesis

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=84954517575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954517575&partnerID=8YFLogxK

U2 - 10.1080/19420889.2015.1017158

DO - 10.1080/19420889.2015.1017158

M3 - Article

AN - SCOPUS:84954517575

VL - 8

SP - 1

EP - 4

JO - Communicative and Integrative Biology

JF - Communicative and Integrative Biology

SN - 1942-0889

IS - 2

ER -