The multiple functions of Numb

Alberto Gulino, Lucia Di Marcotullio, Isabella Screpanti

Research output: Contribution to journalArticlepeer-review

Abstract

Numb is an evolutionary conserved protein that plays critical roles in cell fate determination. Mammalian Numb displays a higher degree of structural complexity compared to the Drosophila homolog based on the number of encoding genes (Numb and Numb-like) and of alternative spliced isoforms. Accordingly, Numb proteins display a complex pattern of functions such as the control of asymmetric cell division and cell fate choice, endocytosis, cell adhesion, cell migration, ubiquitination of specific substrates and a number of signaling pathways (i.e. Notch, Hedgehog, p53). Recent findings indicate that, besides controlling such physiologic developmental processes, subversion of the above Numb-dependent events plays a critical role in disease (e.g. cancer). We will review here the multiple functions of mNumb and their underlying molecular mechanisms in development and disease.

Original languageEnglish
Pages (from-to)900-906
Number of pages7
JournalExperimental Cell Research
Volume316
Issue number6
DOIs
Publication statusPublished - Apr 1 2010

Keywords

  • Asymmetric cell division
  • Cell fate
  • Numb
  • Stem cell

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'The multiple functions of Numb'. Together they form a unique fingerprint.

Cite this