The multiple mechanisms of cell death triggered by resveratrol in lymphoma and leukemia

Raffaele Frazzi, Marco Tigano

Research output: Contribution to journalArticle

Abstract

Lymphoma and leukemia represent a serious threat to human health and life expectancy. Resveratrol is, among the natural-derived chemopreventive molecules, one of the most effective and better studied. In this paper the main mechanisms of cell death triggered by- or linked to- resveratrol are reviewed and discussed. The main focus is on lymphoma and leukemia experimental models where resveratrol has been tested and investigated at the cellular, molecular or physiological levels. The most relevant in vivo challenges involving resveratrol are also reported and analyzed in order to define the key features of this polyphenol and the potential for the treatment of hematologic tumors.

Original languageEnglish
Pages (from-to)4977-4993
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume15
Issue number3
DOIs
Publication statusPublished - Mar 20 2014

Keywords

  • Apoptosis
  • Non-Hodgkin lymphoma
  • Resveratrol

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

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