The multiple personality disorder phenotype(s) of circulating endothelial cells in cancer

Francesco Bertolini, Patrizia Mancuso, Paola Braidotti, Yuval Shaked, Robert S. Kerbel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Circulating endothelial cells (CECs) and circulating endothelial progenitors (CEPs) are currently being investigated in a variety of diseases as markers of vascular turnover or damage and, also in the case of CEPs, vasculogenesis. CEPs appear to have a "catalytic" role in different steps of cancer progression and recurrence after therapy, and there are preclinical and clinical data suggesting that CEC enumeration might be useful to select and stratify patients who are candidates for anti-angiogenic treatments. In some types of cancer, CECs and CEPs might be one of the possible hidden identities of cancer stem cells. The definition of CEC and CEP phenotype and the standardization of CEC and CEP enumeration strategies are highly desirable goals in order to exploit these cells as reliable biomarkers in oncology clinical trials.

Original languageEnglish
Pages (from-to)27-32
Number of pages6
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1796
Issue number1
DOIs
Publication statusPublished - Aug 2009

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Multiple Personality Disorder
Endothelial Cells
Phenotype
Neoplasms
Neoplastic Stem Cells
Blood Vessels
Biomarkers
Clinical Trials
Recurrence
Endothelial Progenitor Cells
Therapeutics

Keywords

  • Angiogenesis
  • Endothelial cells
  • Endothelial progenitors

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Oncology

Cite this

The multiple personality disorder phenotype(s) of circulating endothelial cells in cancer. / Bertolini, Francesco; Mancuso, Patrizia; Braidotti, Paola; Shaked, Yuval; Kerbel, Robert S.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1796, No. 1, 08.2009, p. 27-32.

Research output: Contribution to journalArticle

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