The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis

F. De Maio, F. Squeglia, D. Goletti, G. Delogu

Research output: Contribution to journalArticle

Abstract

A major goal in tuberculosis (TB) research is the identification, among the subjects infected with Mycobacterium tuberculosis (Mtb), of those with active TB, or at higher risk of developing active disease, from the latently infected subjects. The classical heterogeneity of Mtb infection and TB disease is a major obstacle toward the identification of reliable biomarkers that can stratify Mtb infected subjects based on disease risk. The heparin-binding haemagglutinin (HBHA) is a mycobacterial surface antigen that is implicated in tuberculosis (TB) pathogenesis. The host immune response against HBHA varies depending on the TB status and several studies are supporting the role of HBHA as a useful biomarker of TB.
Original languageEnglish
JournalCurrent Medicinal Chemistry
DOIs
Publication statusPublished - Oct 29 2018

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Biomarkers
Tuberculosis
Mycobacterium tuberculosis
Surface Antigens
Mycobacterium Infections
heparin-binding hemagglutinin
human cationic antimicrobial protein CAP 37
Carrier Proteins
Research

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The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis. / Maio, F. De; Squeglia, F.; Goletti, D.; Delogu, G.

In: Current Medicinal Chemistry, 29.10.2018.

Research output: Contribution to journalArticle

Maio, F. De ; Squeglia, F. ; Goletti, D. ; Delogu, G. / The Mycobacterial HBHA Protein: a Promising Biomarker for Tuberculosis. In: Current Medicinal Chemistry. 2018.
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