The Na+Ca2+ exchanger activity in cerebrocortical nerve endings is reduced in old compared to young and mature rats when it operates as a Ca2+ influx or efflux pathway

Lorella M T Canzoniero, Annamaria Rossi, Maurizio Taglialatela, Salvatore Amoroso, Lucio Annunziato, Gianfranco Di Renzo

Research output: Contribution to journalArticle

Abstract

The activity of the Na+Ca2+ exchanger, which regulates the entry and the extrusion of Ca2+ ions from nerve endings was investigated in Percoll-purified cerebrocortical synaptosomes of aged rats. 45Ca2+ uptake in a Na+-free medium and 45Ca2+ efflux in a 145 mM Na+ medium were significantly reduced in cerebrocortical synaptosomes from aged rats (24 months) as compared to those occurring in young (4 months) and mature (14 months) rats. 45Ca2+ influx induced by 55 mM K+, a concentration of K+ ions which selectively promotes Ca2+ entry through voltage-sensitive Ca2+ channels (VSCC), was significantly reduced in mature and aged rats as compared to that occurring in young rats. The impairment of these mechanisms in aged rats is not accompanied by any variation of fura-2 monitored Ca2+ levels under resting and depolarizing conditions.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalBBA - Biomembranes
Volume1107
Issue number1
DOIs
Publication statusPublished - Jun 11 1992

Keywords

  • Aging
  • Calcium ion channel
  • Calcium ion, intracytosolic
  • Cerebrocortical nerve ending
  • Intracytosolic calcium ion
  • Sodium-calcium ion exchanger
  • Voltage sensitivity

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Medicine(all)

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