The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background

Pamela Bulzomi, Alessandro Bolli, Paola Galluzzo, Filippo Acconcia, Paolo Ascenzi, Maria Marino

Research output: Contribution to journalArticlepeer-review

Abstract

Fruit and vegetable consumption has generally been associated with the prevention or suppression of cancer. However, food could contain a multitude of chemicals (e.g., bisphenol A; BPA) that could synergize or antagonize the effects of diet-derived compounds. Remarkably, food containers (e.g., water and infant bottles) are the largest source of exposure to BPA for human beings. Here, the effects of the coexposure of naringenin (Nar, 1.0 × 10 -9 M to 1.0 × 10-4 M) and BPA (1.0 × 10 -5 M) in estrogen-dependent breast cancer cell lines expressing (i.e., MCF-7 and T47D) or not expressing (i.e., MDA-MB-231) estrogen receptor α (ERα) are reported. Although both Nar and BPA bind to ERα, they induce opposite effects on breast cancer cell growth. BPA induces cell proliferation, whereas Nar only decreases the number of ERα-positive cells (i.e., MCF-7 and T47D). Notably, even in the presence of BPA, Nar impairs breast cancer cell proliferation by activating caspase-3. The molecular pathways involved require p38 activation, whereas, the BPA-induced AKT activation is completely prevented by the Nar treatment. As a whole, Nar maintains its proapoptotic effects even in the presence of the food contaminant BPA, thus, enlarging the chemopreventive potential of this flavanone. © 2012 IUBMB IUBMB Life, 64(8): 690-696, 2012

Original languageEnglish
Pages (from-to)690-696
Number of pages7
JournalIUBMB Life
Volume64
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • bisphenol A
  • breast cancer cell lines
  • endocrine disruptors
  • estrogen receptor α
  • naringenin
  • p38

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'The naringenin-induced proapoptotic effect in breast cancer cell lines holds out against a high bisphenol a background'. Together they form a unique fingerprint.

Cite this