The natural mutation by deletion of Lys9 in the thrombin A-chain affects the pKa value of catalytic residues, the overall enzyme's stability and conformational transitions linked to Na+ binding

Raimondo De Cristofaro, Andrea Carotti, Sepideh Akhavan, Roberta Palla, Flora Peyvandi, Cosimo Altomare, Pier Mannuccio Mannucci

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Medicine & Life Sciences

Chemical Compounds