The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death

Agata Copani; Filippo Caraci; J. J M Hoozemans; Marco Calafiore; Maria Angela Sortino; Ferdinando Nicoletti

doi:10.1016/j.bbadis.2006.10.016

The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death

Agata Copani, Filippo Caraci, J. J M Hoozemans, Marco Calafiore, Maria Angela Sortino, Ferdinando Nicoletti

Research output: Contribution to journal › Article › peer-review

Abstract

The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.

Original language	English
Pages (from-to)	409-412
Number of pages	4
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1772
Issue number	4
DOIs	https://doi.org/10.1016/j.bbadis.2006.10.016
Publication status	Published - Apr 2007

Keywords

β-amyloid
Alzheimer's disease
APE-1
Apoptosis
Cell cycle
DNA polymerase-β
DNA Replication

ASJC Scopus subject areas

Biophysics
Molecular Biology
Molecular Medicine

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10.1016/j.bbadis.2006.10.016

Cite this

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abstract = "The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.",

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AU - Calafiore, Marco

AU - Angela Sortino, Maria

AU - Nicoletti, Ferdinando

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The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death

Abstract

Keywords

ASJC Scopus subject areas

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