TY - JOUR
T1 - The nature of the cell cycle in neurons
T2 - Focus on a "non-canonical" pathway of DNA replication causally related to death
AU - Copani, Agata
AU - Caraci, Filippo
AU - Hoozemans, J. J M
AU - Calafiore, Marco
AU - Angela Sortino, Maria
AU - Nicoletti, Ferdinando
PY - 2007/4
Y1 - 2007/4
N2 - The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.
AB - The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.
KW - β-amyloid
KW - Alzheimer's disease
KW - APE-1
KW - Apoptosis
KW - Cell cycle
KW - DNA polymerase-β
KW - DNA Replication
UR - http://www.scopus.com/inward/record.url?scp=33947185406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33947185406&partnerID=8YFLogxK
U2 - 10.1016/j.bbadis.2006.10.016
DO - 10.1016/j.bbadis.2006.10.016
M3 - Article
C2 - 17196375
AN - SCOPUS:33947185406
VL - 1772
SP - 409
EP - 412
JO - Biochimica et Biophysica Acta - Molecular Basis of Disease
JF - Biochimica et Biophysica Acta - Molecular Basis of Disease
SN - 0925-4439
IS - 4
ER -