The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death

Agata Copani, Filippo Caraci, J. J M Hoozemans, Marco Calafiore, Maria Angela Sortino, Ferdinando Nicoletti

Research output: Contribution to journalArticle

Abstract

The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-β, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-β into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.

Original languageEnglish
Pages (from-to)409-412
Number of pages4
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1772
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • β-amyloid
  • Alzheimer's disease
  • APE-1
  • Apoptosis
  • Cell cycle
  • DNA polymerase-β
  • DNA Replication

ASJC Scopus subject areas

  • Biophysics
  • Molecular Biology
  • Molecular Medicine

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