The neovasculature homing motif NGR: More than meets the eye

Angelo Corti, Flavio Curnis, Wadih Arap, Renata Pasqualini

Research output: Contribution to journalArticle

Abstract

A growing body of evidence suggests that peptides containing the Asn-Gly-Arg (NGR) motif can selectively recognize tumor neovasculature and can be used, therefore, for ligand-directed targeted delivery of various drugs and particles to tumors or to other tissues with an angiogenesis component. The neovasculature binding properties of these peptides rely on the interaction with an endotheliumassociated form of aminopeptidase N (CD13), an enzyme that has been implicated in angiogenesis and tumor growth. Recent studies have shown that NGR can rapidly convert to isoaspartate-glycinearginine (isoDGR) by asparagine deamidation, generating 7alpha; vβ 3 ligands capable of affecting endothelial cell functions and tumor growth. This review focuses on structural and functional properties of the NGR motif and its application in drug development for angiogenesisdependent diseases. Furthermore, we discuss the time-dependent transition of NGR to isoDGR in natural proteins, such as fibronectins, and its potential role of as a "molecular timer" for generating new binding sites for integrins implicated in angiogenesis.

Original languageEnglish
Pages (from-to)2628-2635
Number of pages8
JournalBlood
Volume112
Issue number7
DOIs
Publication statusPublished - Oct 1 2008

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Fingerprint Dive into the research topics of 'The neovasculature homing motif NGR: More than meets the eye'. Together they form a unique fingerprint.

  • Cite this