The nervous system in systemic sclerosis (scleroderma). Clinical features and pathogenetic mechanisms

M. M. Cerinic, S. Generini, A. Pignone, R. Casale

Research output: Contribution to journalArticlepeer-review

Abstract

The involvement of the nervous system in SSc is well recognized today. Different pathogenetic mechanisms are suggested that may alternatively explain the multiform appearance of the clinical spectrum (mononeuritis, mononeuritis multiplex, carpal tunnel syndrome, and so forth). It is now clear that the ANS is the earliest structure targeted by the disease in the gastrointestinal tract. The importance of this observation has not yet been adequately interpreted but may, together with the increasing evidence of the nervous system involvement in SSc, become a leading factor in understanding of the importance of the nervous system in the onset, development, and maintenance of the disease.

Original languageEnglish
Pages (from-to)879-892
Number of pages14
JournalRheumatic Disease Clinics of North America
Volume22
Issue number4
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Rheumatology

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