The network integration of epileptic activity in relation to surgical outcome

M Carboni, M Rubega, G R Iannotti, P De Stefano, G Toscano, S Tourbier, F Pittau, P Hagmann, S Momjian, K Schaller, M Seeck, C M Michel, P van Mierlo, S Vulliemoz

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks.

METHODS: We analysed 19 patients with focal epilepsy who had high-density EEG containing IED and underwent surgery. We estimated cortical activity during IED using electric source analysis in 72 atlas-based cortical regions of the individual brain MRI. We applied directed connectivity analysis (information Partial Directed Coherence) and graph analysis on these sources and compared patients with good vs poor post-operative outcome at global, hemispheric and lobar level.

RESULTS: We found lower network integration reflected by global, hemispheric, lobar efficiency during the IED (p < 0.05) in patients with good post-surgical outcome, compared to patients with poor outcome. Prediction was better than using the IED field or the localisation obtained by electric source imaging.

CONCLUSIONS: Abnormal network patterns in epilepsy are related to seizure outcome after surgery.

SIGNIFICANCE: Our finding may help understand networks related to a more "isolated" epileptic activity, limiting the extent of the epileptic network in patients with subsequent good post-operative outcome.

Original languageEnglish
Pages (from-to)2193-2202
Number of pages10
JournalClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Volume130
Issue number12
DOIs
Publication statusPublished - Dec 2019

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Electroencephalography
Epilepsy
Brain
Seizures
Partial Epilepsy
Atlases
Cognitive Dysfunction

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The network integration of epileptic activity in relation to surgical outcome. / Carboni, M; Rubega, M; Iannotti, G R; De Stefano, P; Toscano, G; Tourbier, S; Pittau, F; Hagmann, P; Momjian, S; Schaller, K; Seeck, M; Michel, C M; van Mierlo, P; Vulliemoz, S.

In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, Vol. 130, No. 12, 12.2019, p. 2193-2202.

Research output: Contribution to journalArticle

Carboni, M, Rubega, M, Iannotti, GR, De Stefano, P, Toscano, G, Tourbier, S, Pittau, F, Hagmann, P, Momjian, S, Schaller, K, Seeck, M, Michel, CM, van Mierlo, P & Vulliemoz, S 2019, 'The network integration of epileptic activity in relation to surgical outcome', Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, vol. 130, no. 12, pp. 2193-2202. https://doi.org/10.1016/j.clinph.2019.09.006
Carboni, M ; Rubega, M ; Iannotti, G R ; De Stefano, P ; Toscano, G ; Tourbier, S ; Pittau, F ; Hagmann, P ; Momjian, S ; Schaller, K ; Seeck, M ; Michel, C M ; van Mierlo, P ; Vulliemoz, S. / The network integration of epileptic activity in relation to surgical outcome. In: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2019 ; Vol. 130, No. 12. pp. 2193-2202.
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abstract = "OBJECTIVE: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks.METHODS: We analysed 19 patients with focal epilepsy who had high-density EEG containing IED and underwent surgery. We estimated cortical activity during IED using electric source analysis in 72 atlas-based cortical regions of the individual brain MRI. We applied directed connectivity analysis (information Partial Directed Coherence) and graph analysis on these sources and compared patients with good vs poor post-operative outcome at global, hemispheric and lobar level.RESULTS: We found lower network integration reflected by global, hemispheric, lobar efficiency during the IED (p < 0.05) in patients with good post-surgical outcome, compared to patients with poor outcome. Prediction was better than using the IED field or the localisation obtained by electric source imaging.CONCLUSIONS: Abnormal network patterns in epilepsy are related to seizure outcome after surgery.SIGNIFICANCE: Our finding may help understand networks related to a more {"}isolated{"} epileptic activity, limiting the extent of the epileptic network in patients with subsequent good post-operative outcome.",
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AU - Carboni, M

AU - Rubega, M

AU - Iannotti, G R

AU - De Stefano, P

AU - Toscano, G

AU - Tourbier, S

AU - Pittau, F

AU - Hagmann, P

AU - Momjian, S

AU - Schaller, K

AU - Seeck, M

AU - Michel, C M

AU - van Mierlo, P

AU - Vulliemoz, S

N1 - Copyright © 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - OBJECTIVE: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks.METHODS: We analysed 19 patients with focal epilepsy who had high-density EEG containing IED and underwent surgery. We estimated cortical activity during IED using electric source analysis in 72 atlas-based cortical regions of the individual brain MRI. We applied directed connectivity analysis (information Partial Directed Coherence) and graph analysis on these sources and compared patients with good vs poor post-operative outcome at global, hemispheric and lobar level.RESULTS: We found lower network integration reflected by global, hemispheric, lobar efficiency during the IED (p < 0.05) in patients with good post-surgical outcome, compared to patients with poor outcome. Prediction was better than using the IED field or the localisation obtained by electric source imaging.CONCLUSIONS: Abnormal network patterns in epilepsy are related to seizure outcome after surgery.SIGNIFICANCE: Our finding may help understand networks related to a more "isolated" epileptic activity, limiting the extent of the epileptic network in patients with subsequent good post-operative outcome.

AB - OBJECTIVE: Epilepsy is a network disease with epileptic activity and cognitive impairment involving large-scale brain networks. A complex network is involved in the seizure and in the interictal epileptiform discharges (IEDs). Directed connectivity analysis, describing the information transfer between brain regions, and graph analysis are applied to high-density EEG to characterise networks.METHODS: We analysed 19 patients with focal epilepsy who had high-density EEG containing IED and underwent surgery. We estimated cortical activity during IED using electric source analysis in 72 atlas-based cortical regions of the individual brain MRI. We applied directed connectivity analysis (information Partial Directed Coherence) and graph analysis on these sources and compared patients with good vs poor post-operative outcome at global, hemispheric and lobar level.RESULTS: We found lower network integration reflected by global, hemispheric, lobar efficiency during the IED (p < 0.05) in patients with good post-surgical outcome, compared to patients with poor outcome. Prediction was better than using the IED field or the localisation obtained by electric source imaging.CONCLUSIONS: Abnormal network patterns in epilepsy are related to seizure outcome after surgery.SIGNIFICANCE: Our finding may help understand networks related to a more "isolated" epileptic activity, limiting the extent of the epileptic network in patients with subsequent good post-operative outcome.

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