The neuroanatomy of verbal working memory in schizophrenia: A voxel-based morphometry study

Gianfranco Spalletta, Francesco Tomaiuolo, Margherita Di Paola, Alberto Trequattrini, Pietro Bria, Emiliano Macaluso, Richard S J Frackowiak, Cario Caltagirone

Research output: Contribution to journalArticlepeer-review


Background: Abnormalities of language expression and verbal working memory impairment have been described in schizophrenic subjects. Purpose: To investigate the relationship between verbal working memory performance and cerebral structure in schizophrenic patients and control subjects. Method: Twenty-one Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV) schizophrenic subjects and twenty-one control subjects underwent T1-weighted magnetic resonance imaging (MRI). Grey (GM) and white matter (WM) densities were evaluated using voxel-based morphometry (VBM). We administered the verbal n-back task to assess verbal working memory performance. Findings: A linear regression model, with illness duration included as a covariate, showed that WM density values in the pars opercularis of the left inferior frontal gyrus were positively and specifically correlated (t>7.16, DF=18, r=0.878, p

Original languageEnglish
Pages (from-to)79-87
Number of pages9
JournalClinical Schizophrenia and Related Psychoses
Issue number1
Publication statusPublished - Apr 2008


  • Schizophrenia
  • Voxel-based morphometry (VBM)
  • White matter
  • Working memory

ASJC Scopus subject areas

  • Psychiatry and Mental health


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