The neuropeptide alpha-melanocyte-stimulating hormone: a key component of neuroimmunomodulation.

A. Catania, J. M. Lipton

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Recent research indicates that the proopiomelanocortin derivative alpha-melanocyte stimulating hormone (alpha-MSH) is a significant modulator of host reactions including fever and inflammation. Although the precise mechanism of action is still unknown, cytokine antagonism is believed to be responsible for at least a part of its anti-inflammatory/antipyretic influence: alpha-MSH antagonizes pyrogenic and proinflammatory effects of cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor (TNF), and interferon gamma (IFN gamma). Although it is clear that the peptide can act within the brain to inhibit fever and peripheral inflammation, an anti-inflammatory effect on a peripheral target was evidenced in animals with transection of the spinal cord. Recent data show that alpha-MSH is significant also in human disorders such as AIDS, rheumatoid arthritis, and myocardial infarction. This molecule is believed to be a key factor in neuroimmunomodulation and it may be useful as a therapeutic agent in control of inflammatory reactions.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalNeuroImmunoModulation
Volume1
Issue number2
Publication statusPublished - Mar 1994

Fingerprint

Neuroimmunomodulation
alpha-MSH
Neuropeptides
Anti-Inflammatory Agents
Fever
Cytokines
Inflammation
Pro-Opiomelanocortin
Antipyretics
Spinal Cord Injuries
Interleukin-1
Interferon-gamma
Interleukin-6
Rheumatoid Arthritis
Acquired Immunodeficiency Syndrome
Tumor Necrosis Factor-alpha
Myocardial Infarction
Peptides
Brain
Research

ASJC Scopus subject areas

  • Endocrinology
  • Immunology
  • Neuroscience(all)

Cite this

The neuropeptide alpha-melanocyte-stimulating hormone : a key component of neuroimmunomodulation. / Catania, A.; Lipton, J. M.

In: NeuroImmunoModulation, Vol. 1, No. 2, 03.1994, p. 93-99.

Research output: Contribution to journalArticle

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