The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats

Giuliana Ceriani, Julie Diaz, Sidney Murphree, Anna Catania, James M. Lipton

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

a-Melanocyte-stimulating hormone (α-MSH) modulates inflammatory processes in models of acute inflammation and in models of sepsis/septic shock/adult respiratory-distress syndrome (ARDS). Because this neuropeptide inhibits actions of cytokines and other mediators of imflammation that are also believed to underlie aspects of chronic inflammation, tests were performed to compare the effects of repeated administration of the peptide with those of prednisolone and saline on the development of adjuvant arthritis in rats, a- MSH (50 μg), injected i.p. twice daily, markedly inhibited the clinical and histological signs of experimental arthritis and moderated the weight loss observed in control animals. Prednisolone (100 mg/kg), given twice per day, prevented development of arthritis but caused marked and progressive weight loss. The results confirm the potent anti-inflammatory influence of a-MSH, in this case in a model of chronic inflammation that has immune components.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalNeuroImmunoModulation
Volume1
Issue number1
DOIs
Publication statusPublished - 1994

Fingerprint

Melanocyte-Stimulating Hormones
alpha-MSH
Experimental Arthritis
Neuropeptides
Prednisolone
Inflammation
Weight Loss
Adult Respiratory Distress Syndrome
Septic Shock
Arthritis
Sepsis
Anti-Inflammatory Agents
Cytokines
Peptides

Keywords

  • Adjuvant arthritis
  • Inflammation
  • Neuroimmunomodulation
  • Neuropeptide
  • Prednisolone
  • Steroid-induced weight loss
  • α-Melanocyte-stimulating hormone

ASJC Scopus subject areas

  • Endocrinology
  • Immunology
  • Endocrine and Autonomic Systems
  • Neurology
  • Neuroscience(all)

Cite this

The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. / Ceriani, Giuliana; Diaz, Julie; Murphree, Sidney; Catania, Anna; Lipton, James M.

In: NeuroImmunoModulation, Vol. 1, No. 1, 1994, p. 28-32.

Research output: Contribution to journalArticle

Ceriani, Giuliana ; Diaz, Julie ; Murphree, Sidney ; Catania, Anna ; Lipton, James M. / The neuropeptide alpha-melanocyte-stimulating hormone inhibits experimental arthritis in rats. In: NeuroImmunoModulation. 1994 ; Vol. 1, No. 1. pp. 28-32.
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