The neuropsychological and neuroradiological correlates of slowly progressive visual agnosia

Anna Rita Giovagnoli, Anna Aresi, Fabiola Reati, Alice Riva, Clara Gobbo, Alberto Bizzi

Research output: Contribution to journalArticlepeer-review


The case of a 64-year-old woman affected by slowly progressive visual agnosia is reported aiming to describe specific cognitive-brain relationships. Longitudinal clinical and neuropsychological assessment, combined with magnetic resonance imaging (MRI), spectroscopy, and positron emission tomography (PET) were used. Sequential neuropsychological evaluations performed during a period of 9 years since disease onset showed the appearance of apperceptive and associative visual agnosia, alexia without agraphia, agraphia, finger agnosia, and prosopoagnosia, but excluded dementia. MRI showed moderate diffuse cortical atrophy, with predominant atrophy in the left posterior cortical areas (temporal, parietal, and lateral occipital cortical gyri). 18FDG-PET showed marked bilateral posterior cortical hypometabolism; proton magnetic resonance spectroscopic imaging disclosed severe focal N-acetyl-aspartate depletion in the left temporoparietal and lateral occipital cortical areas. In conclusion, selective metabolic alterations and neuronal loss in the left temporoparietooccipital cortex may determine progressive visual agnosia in the absence of dementia.

Original languageEnglish
Pages (from-to)123-131
Number of pages9
JournalNeurological Sciences
Issue number2
Publication statusPublished - 2009


  • Cognitive impairment
  • Dementia
  • Neuroimaging
  • Slowly progressive visual agnosia

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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