The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI)

Ombretta Annibali; Stefan Hohaus; Francesco Marchesi; Maria Cantonetti; Alice Di Rocco; Valeria Tomarchio; Arianna Di Napoli; Sabrina Pelliccia; Roberta Battistini; Paola Anticoli Borza; Elisabetta Abruzzese; Natalia Cenfra; Alessandro Andriani; Cristiano Tesei; Eleonora Alma; Francesca Palombi; Livio Pupo; Luigi Petrucci; Marco Becilli; Elena Maiolo; Silvia Bellesi; Annarosa Cuccaro; Francesco D’Alò; Maria Christina Cox

doi:10.1080/10428194.2019.1633628

The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI)

Ombretta Annibali, Stefan Hohaus, Francesco Marchesi, Maria Cantonetti, Alice Di Rocco, Valeria Tomarchio, Arianna Di Napoli, Sabrina Pelliccia, Roberta Battistini, Paola Anticoli Borza, Elisabetta Abruzzese, Natalia Cenfra, Alessandro Andriani, Cristiano Tesei, Eleonora Alma, Francesca Palombi, Livio Pupo, Luigi Petrucci, Marco Becilli, Elena MaioloSilvia Bellesi, Annarosa Cuccaro, Francesco D’Alò, Maria Christina Cox

Istituto Regina Elena

Research output: Contribution to journal › Article › peer-review

Abstract

In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio ≥3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).

Original language	English
Pages (from-to)	3386-3394
Number of pages	9
Journal	Leukemia and Lymphoma
Volume	60
Issue number	14
DOIs	https://doi.org/10.1080/10428194.2019.1633628
Publication status	Published - Dec 6 2019

Keywords

cancer
DLBCL
lymphoma
N/L ratio
R-CHOP

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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Annibali, O., Hohaus, S., Marchesi, F., Cantonetti, M., Di Rocco, A., Tomarchio, V., Di Napoli, A., Pelliccia, S., Battistini, R., Anticoli Borza, P., Abruzzese, E., Cenfra, N., Andriani, A., Tesei, C., Alma, E., Palombi, F., Pupo, L., Petrucci, L., Becilli, M., ... Cox, M. C. (2019). The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI). Leukemia and Lymphoma, 60(14), 3386-3394. https://doi.org/10.1080/10428194.2019.1633628

The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma : a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI). / Annibali, Ombretta; Hohaus, Stefan; Marchesi, Francesco; Cantonetti, Maria; Di Rocco, Alice; Tomarchio, Valeria; Di Napoli, Arianna; Pelliccia, Sabrina; Battistini, Roberta; Anticoli Borza, Paola; Abruzzese, Elisabetta; Cenfra, Natalia; Andriani, Alessandro; Tesei, Cristiano; Alma, Eleonora; Palombi, Francesca; Pupo, Livio; Petrucci, Luigi; Becilli, Marco; Maiolo, Elena; Bellesi, Silvia; Cuccaro, Annarosa; D’Alò, Francesco; Cox, Maria Christina.

In: Leukemia and Lymphoma, Vol. 60, No. 14, 06.12.2019, p. 3386-3394.

Research output: Contribution to journal › Article › peer-review

Annibali, O, Hohaus, S, Marchesi, F, Cantonetti, M, Di Rocco, A, Tomarchio, V, Di Napoli, A, Pelliccia, S, Battistini, R, Anticoli Borza, P, Abruzzese, E, Cenfra, N, Andriani, A, Tesei, C, Alma, E, Palombi, F, Pupo, L, Petrucci, L, Becilli, M, Maiolo, E, Bellesi, S, Cuccaro, A, D’Alò, F & Cox, MC 2019, 'The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI)', Leukemia and Lymphoma, vol. 60, no. 14, pp. 3386-3394. https://doi.org/10.1080/10428194.2019.1633628

Annibali O, Hohaus S, Marchesi F, Cantonetti M, Di Rocco A, Tomarchio V et al. The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma: a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI). Leukemia and Lymphoma. 2019 Dec 6;60(14):3386-3394. https://doi.org/10.1080/10428194.2019.1633628

Annibali, Ombretta ; Hohaus, Stefan ; Marchesi, Francesco ; Cantonetti, Maria ; Di Rocco, Alice ; Tomarchio, Valeria ; Di Napoli, Arianna ; Pelliccia, Sabrina ; Battistini, Roberta ; Anticoli Borza, Paola ; Abruzzese, Elisabetta ; Cenfra, Natalia ; Andriani, Alessandro ; Tesei, Cristiano ; Alma, Eleonora ; Palombi, Francesca ; Pupo, Livio ; Petrucci, Luigi ; Becilli, Marco ; Maiolo, Elena ; Bellesi, Silvia ; Cuccaro, Annarosa ; D’Alò, Francesco ; Cox, Maria Christina. / The neutrophil/lymphocyte ratio ≥3.5 is a prognostic marker in diffuse large B-cell lymphoma : a retrospective analysis from the database of the Italian regional network ‘Rete Ematologica del Lazio per i Linfomi’ (RELLI). In: Leukemia and Lymphoma. 2019 ; Vol. 60, No. 14. pp. 3386-3394.

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abstract = "In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio ≥3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).",

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AU - Annibali, Ombretta

AU - Hohaus, Stefan

AU - Marchesi, Francesco

AU - Cantonetti, Maria

AU - Di Rocco, Alice

AU - Tomarchio, Valeria

AU - Di Napoli, Arianna

AU - Pelliccia, Sabrina

AU - Battistini, Roberta

AU - Anticoli Borza, Paola

AU - Abruzzese, Elisabetta

AU - Cenfra, Natalia

AU - Andriani, Alessandro

AU - Tesei, Cristiano

AU - Alma, Eleonora

AU - Palombi, Francesca

AU - Pupo, Livio

AU - Petrucci, Luigi

AU - Becilli, Marco

AU - Maiolo, Elena

AU - Bellesi, Silvia

AU - Cuccaro, Annarosa

AU - D’Alò, Francesco

AU - Cox, Maria Christina

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N2 - In solid tumors and lymphomas, the neutrophil/lymphocyte (N/L) ratio at diagnosis has been shown to be a prognostic factor. The aim of our study was to validate the originally reported N/L ratio cut-point of 3.5 in patients with diffuse large B-cell lymphoma (DLBCL) registered in an Italian real-life database. The prognostic role of the N/L ratio at diagnosis on event-free survival (EFS) and overall survival (OS) was assessed in 505 patients with DLBCL. Patients with an N/L ratio <3.5 (n = 249) had a 4-year EFS probability of 76% and OS probability of 86%, significantly higher than the 4 year EFS rate of 48% and OS rate of 64% in patients with N/L ratio ≥3.5 (n = 256, both p<.0001). The N/L ratio was an independent prognostic factor in the multivariate analysis including the IPI score, and could separate patients with a low/intermediate risk IPI (IPI <3).

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