The new antigenic ecospace of the globalized world and its impact on the immune system: The battleground of trade-off and antagonistic pleiotropy

Miriam Capri, Stefano Salvioli, Daniela Monti, Laura Bucci, Paolo Garagnani, Enzo Ottaviani, Claudio Franceschi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Like almost all vertebrates, humans have developed a complex immune system, which evolved in an environment that prompted the development of sophisticated strategies of antigen recognition due to the necessity to discriminate relatively few pathogens among huge amounts of commensal microorganisms, and tolerate self antigens as well as food antigens. The universe of antigens that driven this evolution could be suggestively called antigenic ecospace. In this chapter, we will discuss how rapid changes in this ecospace due to its globalization as a consequence of new population and economic worldwide dynamics can impact on immune functions and eventually on health status of the individuals.

Original languageEnglish
Title of host publicationEco-immunology: Evolutive Aspects and Future Perspectives
PublisherSpringer Netherlands
Pages125-144
Number of pages20
ISBN (Print)9789401787123, 9401787115, 9789401787116
DOIs
Publication statusPublished - Jan 1 2014

Keywords

  • Aging
  • Antigenic ecospace
  • Gut microbiota
  • Inflammaging
  • Nutrition

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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