LE FACTUER TRANSCRIPTIONNEL NF-κB: ROLE AU COURS DE L'ONCOGENESE ET DE LA REPONSE AU TRAITEMENT ANTICANCEREUX

Translated title of the contribution: The NF-κB transcription factor: Role in oncogenesis and in response to anticancer therapeutics

Vincent Bours, Emmanuel Dejardin, Giuseppina Bonizzi, Marie Paule Merville, Jacques Piette

Research output: Contribution to journalArticlepeer-review

Abstract

The NF-κB transcription factor is a central mediator of immune response and inflammation. Several lines of evidence also support a role for NF-κB in oncogenesis and cancer progression. However, with the exception of the oncoprotein v-Rel, a direct oncogenicity by Rel/NF-κB proteins has not yet been demonstrated. It is conceivable that, according to the cellular context and the stage of cancer, an activation or an inhibition of cellular NF-κB activity might participate in tumor progression. On another hand, NF-κB is clearly involved in the control of apoptosis and cellular response to DNA damage following treatment with cytotoxic anticancer treatments. NF-κB inhibits apoptosis after cellular treatment with TNF-α or DNA-damaging agents. Therefore, the development of drugs that inhibit NF-κB should allow a significant increase of cytotoxicity induced by anticancer chemotherapy.

Translated title of the contributionThe NF-κB transcription factor: Role in oncogenesis and in response to anticancer therapeutics
Original languageFrench
Pages (from-to)566-571
Number of pages6
JournalMedecine/Sciences
Volume14
Issue number5
Publication statusPublished - May 1998

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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