Abstract
The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.
| Original language | English |
|---|---|
| Pages (from-to) | 69-123 |
| Number of pages | 55 |
| Journal | Critical Reviews in Biochemistry and Molecular Biology |
| Volume | 29 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 |
Keywords
- Ionotropic neurotransmitter receptors
- Ligand-gated ion channels
- Myasthenia gravis
- Nicotinic receptor
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
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Cite this
Conti-Tronconi, B. M., Mclane, K. E., Raftery, M. A., Grando, S. A., & Protti, M. P. (1994). The nicotinic acetylcholine receptor: Structure and autoimmune pathology. Critical Reviews in Biochemistry and Molecular Biology, 29(2), 69-123. https://doi.org/10.3109/10409239409086798