The nicotinic acetylcholine receptor: Structure and autoimmune pathology

Bianca M. Conti-Tronconi, Kathryn E. Mclane, Michael A. Raftery, Sergei A. Grando, Maria Pia Protti

Research output: Contribution to journalArticlepeer-review


The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.

Original languageEnglish
Pages (from-to)69-123
Number of pages55
JournalCritical Reviews in Biochemistry and Molecular Biology
Issue number2
Publication statusPublished - 1994


  • Ionotropic neurotransmitter receptors
  • Ligand-gated ion channels
  • Myasthenia gravis
  • Nicotinic receptor

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry


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