TY - JOUR
T1 - The nicotinic acetylcholine receptor
T2 - Structure and autoimmune pathology
AU - Conti-Tronconi, Bianca M.
AU - Mclane, Kathryn E.
AU - Raftery, Michael A.
AU - Grando, Sergei A.
AU - Protti, Maria Pia
PY - 1994
Y1 - 1994
N2 - The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.
AB - The nicotinic acetylcholine receptors (AChR) are presently the best-characterized neurotransmitter receptors. They are pentamers of homologous or identical subunits, symmetrically arranged to form a transmembrane cation channel. The AChR subunits form a family of homologous proteins, derived from a common ancestor. An autoimmune response to muscle AChR causes the disease myasthenia gravis. This review summarizes recent developments in the understanding of the AChR structure and its molecular recognition by the immune system in myasthenia.
KW - Ionotropic neurotransmitter receptors
KW - Ligand-gated ion channels
KW - Myasthenia gravis
KW - Nicotinic receptor
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U2 - 10.3109/10409239409086798
DO - 10.3109/10409239409086798
M3 - Article
C2 - 8026215
AN - SCOPUS:0028299642
VL - 29
SP - 69
EP - 123
JO - Critical Reviews in Biochemistry and Molecular Biology
JF - Critical Reviews in Biochemistry and Molecular Biology
SN - 1040-9238
IS - 2
ER -