The non-coding RNA landscape of plasma cell dyscrasias

Eugenio Morelli, Annamaria Gullà, Roberta Rocca, Cinzia Federico, Lavinia Raimondi, Stefano Malvestiti, Valter Agosti, Marco Rossi, Giosuè Costa, Gianluca Giavaresi, Kareem A. Azab, Antonia Cagnetta, Michele Cea, Pierosandro Tagliaferri, Antonino Neri, Nikhil C. Munshi, Giuseppe Viglietto, Pierfrancesco Tassone, Nicola Amodio

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.

Original languageEnglish
Article number320
JournalCancers
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 2020

Keywords

  • LncRNA
  • MiRNA
  • Multiple myeloma
  • Non-coding RNA
  • Plasma cell dyscrasia

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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